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首页> 外文期刊>Respirology : >Clinical implications of initial peripheral eosinophiiia in acute - eosinophilic pneumonia
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Clinical implications of initial peripheral eosinophiiia in acute - eosinophilic pneumonia

机译：初始外周嗜酸性粒细胞增多症在急性嗜酸性粒细胞性肺炎中的临床意义

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摘要

Background and objective: The initial peripheral eosinophil count (PECJ is rarely elevated but tends to increase during the clinical course of acute eosinophilic pneumonia (AEP). We evaluated whether initial peripheral eosinophiiia is an indicator of mild disease in patients with AEP. Methods: We retrospectively examined associations between initial peripheral absolute eosinophil count, inflammatory markers and clinical characteristics in 85 patients with AEP. Results: Of 85 patients, 24 (28%) had initial peripheral eosinophiiia (>500/muL). Initial peripheral absolute eosinophil count was inversely correlated to white blood cell (WBC) count (p =-0.386, P< 0.001), neutrophii percentage (p = -0.645, P < 0.001) and C-reactive protein (CRP; p = -0.495, P < 0.001). During treatment, peripheral absolute eosinophil counts increased, while inflammatory markers (WBC, neutrophii percentage, and CRP) decreased. Patients with initial peripheral eosinophiiia had a longer duration from onset of symptoms to admission (P = 0.006), had lower WBC counts, neutrophii percentages and CRP values (all P < 0.001), and higher oxygen saturation (P = 0.004) than patients with normal peripheral eosinophil counts. Oxygen requirements (P = 0.013), duration of oxygen administration (P = 0.028) and intensive care unit admission rates (P = 0.003) were lower in patients with initial peripheral eosinophiiia. All patients survived and recovered fully after corticosteroid or conservative treatment. Conclusions: Initial PEC may be related to a milder disease status on admission, compared with normal PEC in patients with AEP. This may help to stratify disease severity in AEP.
机译：背景与目的：急性嗜酸性粒细胞性肺炎（AEP）的临床过程中，初始外周嗜酸性粒细胞计数（PECJ很少升高，但趋于增加），我们评估了初始外周嗜酸性粒细胞是否是AEP患者轻度疾病的指标。回顾性分析了85例AEP患者外周血嗜酸性粒细胞初始计数，炎症标志物与临床特征之间的相关性。结果：85例患者中有24例（28％）外周血嗜酸性粒细胞（> 500 /μL），外周血嗜酸性粒细胞初始计数反与白细胞（WBC）计数（p = -0.386，P <0.001），中性粒细胞百分比（p = -0.645，P <0.001）和C反应蛋白（CRP; p = -0.495，P <0.001）相关。在治疗过程中，外周嗜酸性粒细胞绝对计数增加，而炎症标志物（白细胞，中性粒细胞百分比和CRP）降低，初始外周嗜酸性粒细胞的患者从症状发作开始的时间更长与正常外周嗜酸性粒细胞计数的患者相比，入院前的Tom（P = 0.006），具有较低的白细胞计数，中性粒细胞百分比和CRP值（所有P <0.001）和较高的血氧饱和度（P = 0.004）。初始外周嗜酸性粒细胞减少患者的需氧量（P = 0.013），用氧时间（P = 0.028）和重症监护病房入院率（P = 0.003）较低。皮质类固醇或保守治疗后所有患者均存活并完全康复。结论：与AEP患者的正常PEC相比，初始PEC可能与入院时病情较轻有关。这可能有助于对AEP中的疾病严重程度进行分层。

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