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首页> 外文期刊>Reviews of physiology, biochemistry and pharmacology. >Cytochrome c oxidase - structure, function, and physiology of a redox-driven molecular machine
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Cytochrome c oxidase - structure, function, and physiology of a redox-driven molecular machine

机译：细胞色素C氧化酶-氧化还原驱动分子机器的结构，功能和生理学

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摘要

Cytochome c oxidase is the terminal member of the electron transport chains of mitochondria and many bacteria. Providing an efficient mechanism for dioxygen reduction on the one hand, it also acts as a redox-linked proton pump, coupling the free energy of water formation to the generation of a transmembrane electrochemical gradient to eventually drive ATP synthesis. The overall complexity of the mitochondrial enzyme is also reflected by its subunit structure and assembly pathway, whereas the diversity of the bacterial enzymes has fostered the notion of a large family of heme-copper terminal oxidases. Moreover, the successful elucidation of 3-D structures for both the mitochondrial and several bacterial oxidases has greatly helped in designing mutagenesis approaches to study functional aspects in these enzymes.
机译：Cytochome c氧化酶是线粒体和许多细菌的电子传输链的末端成员。一方面，它提供了一种有效的还原双氧的机制，还充当了氧化还原连接的质子泵，将水形成的自由能与跨膜电化学梯度的产生耦合在一起，最终推动了ATP的合成。线粒体酶的整体复杂性也通过其亚基结构和组装途径反映出来，而细菌酶的多样性促进了大家族血红素-铜末端氧化酶的概念。此外，线粒体和几种细菌氧化酶的3-D结构的成功阐明极大地帮助设计了诱变方法来研究这些酶的功能方面。

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