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Gender dimorphism in skeletal muscle proteome between lean and diet-induced obese rats

机译：肥胖和饮食诱导的肥胖大鼠骨骼肌蛋白质组中的性别差异

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Although it has been believed for a long time that gender differences in physiology and metabolism were not relevant beyond the reproductive system, new research has indicated that sexual dimorphism may be more prevalent than previously believed. Therefore, the goal of this study was to develop a global view of the changes in gender-dependent protein abundance in two different types of skeletal muscles (soleus and gastrocnemius) of lean and high fat diet (HFD)-induced obese rats. Methods: To examine differential expression of proteins between gender and diet, we performed differential proteome analysis of skeletal muscle from lean and obese rats of both genders fed a HFD using 2-DE combined with MALDI-TOF-MS. Results: Our gender-specific proteome comparison showed that male and female rats displayed different patterns of proteome regulation including proteins involved in muscle contraction, carbohydrate and lipid metabolism, oxidative phosphorylation, as well as detoxification and antioxidant defenses. Conclusions: most of the candidate proteins identified herein by differential proteomics were previously unrecognized in gender dimorphism of skeletal muscle. Our data can serve as the basis for specific evidence-based interventions allowing for the prevention and treatment of obesity by matching the different needs of women and men such as the development of gender-based medicine.
机译：尽管人们长期以来一直认为生理和代谢方面的性别差异与生殖系统无关，但新的研究表明，性二态性可能比以前认为的更为普遍。因此，本研究的目的是对瘦高脂肪饮食（HFD）诱发的肥胖大鼠的两种不同类型的骨骼肌（比目鱼肌和腓肠肌）的性别依赖性蛋白丰度变化进行全面研究。方法：为检验性别与饮食之间蛋白质的差异表达，我们对使用2-DE结合MALDI-TOF-MS进行HFD饲喂HFD的瘦弱和肥胖的两种性别的肥胖大鼠的骨骼肌进行了蛋白质组分析。结果：我们的性别蛋白质组比较显示，雄性和雌性大鼠表现出不同的蛋白质组调节模式，包括参与肌肉收缩，碳水化合物和脂质代谢，氧化磷酸化以及排毒和抗氧化防御的蛋白质。结论：本文中通过差异蛋白质组学鉴定的大多数候选蛋白质以前在骨骼肌性别二态性中未被识别。我们的数据可以作为基于证据的具体干预措施的基础，这些干预措施可以通过匹配男女的不同需求（例如基于性别的医学的发展）来预防和治疗肥胖。

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