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首页> 外文期刊>Rheumatology >Protein oxidation status in patients with ankylosing spondylitis.
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Protein oxidation status in patients with ankylosing spondylitis.

机译：强直性脊柱炎患者的蛋白质氧化状态。

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OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory disease with unknown aetiology. Since various functions of neutrophils are increased in AS, neutrophil activation-mediated oxidative stress may have an important role in the pathogenesis of AS. Therefore, the importance of neutrophil activation as the main source of oxidative stress was investigated in patients with AS. METHODS: Forty-one patients with AS, divided into active and inactive groups according to their CRP and ESR, and 30 healthy volunteers were entered into the study. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the visual analogue scale (VAS) were also used in all patients before the study. In addition, the patients were evaluated according to spinal involvement and peripheral involvement. Plasma myeloperoxidase (MPO) activity, representing neutrophil activation, and oxidative stress biomarkers, such as advanced oxidation protein products (AOPP) and thiol levels, were measured. RESULTS: There were significant increases in plasma MPO activity and AOPP but decreases in thiol levels in the total AS patient group and in the subgroups, compared with controls. All parameters, except thiol, were higher in active and peripheral involvement groups than in the inactive and spinal patients, respectively; but the highest levels were observed in the peripheral subgroup. In addition, AOPP was found to be positively correlated with ESR, CRP and BASDAI in the total patient group and with white blood cell and neutrophil count in the peripheral involvement subgroup. BASDAI was positively correlated with VAS, ESR and CRP; but MPO was negatively correlated with thiol/albumin ratio, both in total and active AS patients. Negative correlations were also observed between albumin and ESR, and between CRP and neutrophil counts in the peripheral subgroup. CONCLUSIONS: This is the first study suggesting neutrophil-MPO-hypochlorous acid-mediated AOPP formation in AS. Therefore, active neutrophils and chlorinated oxidants of neutrophil origin may be considered to be important factors in the pathogenesis of AS which are related to oxidative stress, notably protein oxidation.
机译：目的：强直性脊柱炎（AS）是一种病因不明的慢性炎症性疾病。由于嗜中性粒细胞的各种功能在AS中增加，因此嗜中性粒细胞活化介导的氧化应激可能在AS的发病机理中起重要作用。因此，研究了AS患者中嗜中性粒细胞活化作为氧化应激的主要来源的重要性。方法：将41例AS患者按其CRP和ESR分为活跃和不活跃组，并选择30名健康志愿者作为研究对象。在研究之前，所有患者均使用了巴斯强直性脊柱炎疾病活动指数（BASDAI）和视觉模拟量表（VAS）。另外，根据脊柱受累和周围受累对患者进行评估。测量了代表中性粒细胞活化的血浆髓过氧化物酶（MPO）活性，以及​​氧化应激生物标志物，例如高级氧化蛋白产物（AOPP）和硫醇水平。结果：与对照组相比，总AS患者组和亚组的血浆MPO活性和AOPP显着增加，但硫醇水平降低。在活动和周围受累组中，除巯基外，所有参数均分别高于非活动和脊柱病患者。但在外周亚组中观察到最高水平。此外，在整个患者组中，AOPP与ESR，CRP和BASDAI呈正相关，而在外周受累亚组中与白细胞和中性粒细胞计数呈正相关。 BASDAI与VAS，ESR和CRP呈正相关。但无论是全部还是活跃的AS患者，MPO与硫醇/白蛋白之比均呈负相关。在外周血亚组中，白蛋白和ESR之间以及CRP和中性粒细胞计数之间也观察到负相关。结论：这是第一项研究提示中性粒细胞-MPO-次氯酸介导的AS中AOPP的形成。因此，活性中性粒细胞和中性粒细胞来源的氯化氧化剂可能被认为是AS发病机理中与氧化应激特别是蛋白质氧化有关的重要因素。

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