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meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity

机译：介观取代的BODIPY荧光探针可用于细胞生物成像和抗癌活性

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A series of meso-substituted thienyl BODIPY analogues (1, 1a-g) have been designed and synthesized. Among those, compounds 1c, 1d and 1e show biocompatibility towards endothelial cells whereas 1c and 1d show significant cytotoxicity towards cancerous cells. The formation of intracellular reactive oxygen species (ROS) and the activation of the apoptotic protein may be a plausible mechanism for the anti-proliferative nature of 1c and 1d. Additionally, compounds 1c, 1d, and 1e fluoresce inside the cancer cells. The combined results suggest the future theranostic (therapeutics + diagnostics) applications of 1c and 1d in cancer diseases.

机译：已经设计并合成了一系列内消旋的噻吩基BODIPY类似物（1、1a-g）。其中，化合物1c，1d和1e对内皮细胞具有生物相容性，而化合物1c和1d对癌细胞具有明显的细胞毒性。细胞内活性氧（ROS）的形成和凋亡蛋白的激活可能是1c和1d抗增殖性质的合理机制。此外，化合物1c，1d和1e在癌细胞内发荧光。结合的结果表明1c和1d在癌症治疗中的未来治疗学（治疗学+诊断学）应用。

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《RSC Advances》 |2014年第88期|共5页
作者
Gayathri Thumuganti; Barui Ayan Kumar; Prashanthi Suthari; Patra Chitta Ranjan; Singh Surya Prakash;
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正文语种 eng
中图分类化学;
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1. meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity [J] . Gayathri Thumuganti, Barui Ayan Kumar, Prashanthi Suthari, RSC Advances . 2014,第88期

机译：介观取代的BODIPY荧光探针可用于细胞生物成像和抗癌活性
2. Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging [J] . Yong Ni, Jishan Wu Organic & biomolecular chemistry . 2014,第23期

机译：远红和近红外BODIPY染料：荧光pH探针和生物成像的合成及应用
3. Organization of inner cellular components as reported by a viscosity-sensitive fluorescent Bodipy probe suitable for phasor approach to FLIM [J] . Gianmarco Ferri, Luca Nucara, Tarita Biver, Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2015,第期

机译：由粘度敏感的荧光BOBIPY探针报告的内部细胞组分组织适用于PHASOR方法
4. Fluorescent pH probes, Fluorescent Proteins, and Intrinsic Cellular Fluorochromes are Tools to Study Cytosolic pH (pH~(cyt)) in Mammalian Cells [C] . Gloria M. Martinez, Lauren S. Gollahon, Keri Shafer, Society of Photo-Optical Instrumentation Engineers Conference on Biomarkers and Biological Spectral Imaging . 2001

机译：荧光pH探针，荧光蛋白和固有细胞荧光致荧光剂是在哺乳动物细胞中研究细胞溶胶pH（pH〜（cyt））的工具
5. Design and development of bodipy-based fluorescent probes for sensing and imaging of cyanide, Zn (II) ions, lysosomal ph and cancer cells [D] . Zhang, Jingtuo 2015

机译：基于人体的荧光探针的设计和开发，用于感测和成像氰化物，Zn（II）离子，溶酶体ph和癌细胞
6. Synthesis of Functional Fluorescent BODIPY‐based Dyes through Electrophilic Aromatic Substitution: Straightforward Approach towards Customized Fluorescent Probes [O] . Dr. Giorgio Mirri, Daniël C. Schoenmakers, Dr. Paul H. J. Kouwer, 2016

机译：通过亲电芳族取代合成功能性基于BODIPY的荧光染料：定制荧光探针的简单方法
7. Correction: meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity [O] . Thumuganti Gayathri, Ayan Kumar Barui, Suthari Prashanthi, 2014

机译：校正：中间替代的细胞生物成像和抗癌活性的BOBIPY荧光探针

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