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首页> 外文期刊>Optics Letters >Separation of changes in light scattering and chromophore concentrations during cortical spreading depression in rats
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Separation of changes in light scattering and chromophore concentrations during cortical spreading depression in rats

机译：大鼠皮层扩散抑制过程中光散射和发色团浓度变化的分离

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We used near-infrared spectroscopy to separate tissue scattering changes from changes in cerebral oxyhemoglobin and deoxyhemoglobin and the redox state of cytochrome-c-oxidase. A separate term of the transport scattering coefficient (mu(s)') was included in a modified Lambert-Beer equation. It is shown by diffusion equation analysis that there is a simple relationship between the differential path-length factor (D-a) and its scattering equivalent (D-s). The method was applied to cortical spreading depression (CSD) data recorded through the skulls of rats. Biphasic changes in mu(s)' of +/-0.1 mm(-1) were observed during CSD's that spread with a velocity of similar to 5 mm/min. The method proposed has the promise to permit monitoring of scattering changes noninvasively in humans during cortical activation or pathophysiological conditions. (C) 1998 Optical Society of America. [References: 17]
机译：我们使用近红外光谱法将组织散射变化与脑中氧合血红蛋白和脱氧血红蛋白的变化以及细胞色素C-氧化酶的氧化还原状态分开。修正的Lambert-Beer方程中包括了传输散射系数（mu（s）'）的单独项。通过扩散方程分析表明，在微分路径长度因子（D-a）和其散射当量（D-s）之间存在简单的关系。该方法适用于通过大鼠头骨记录的皮质扩散抑制（CSD）数据。在CSD期间观察到以+/- 0.1 mm（-1）的mu（s）的双相变化，其传播速度接近5 mm / min。所提出的方法有望允许在皮层激活或病理生理状况期间无创地监测人类的散射变化。 （C）1998年美国眼镜学会。 [参考：17]

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