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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >The role of Helicobacter pylori infection in the cause of squamous cell carcinoma of the larynx.
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The role of Helicobacter pylori infection in the cause of squamous cell carcinoma of the larynx.

机译：幽门螺杆菌感染在喉鳞状细胞癌病因中的作用。

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OBJECTIVE: Helicobacter pylori can cause chronic infection that has been linked to the development of both benign and malignant disease of the aerodigestive tract. The purpose of this study was to determine the link between H pylori infection and squamous cell carcinoma of the larynx (SCCL). METHODS: We estimated the presence of IgG antibodies against H pylori antigens by using ELISA technique in the sera of 26 patients with SCCL and 32 matched controls without carcinoma of the larynx. RESULTS: The incidence of seropositivity of patients with SCCL was 73.07% and of controls was 40.62%. These data support an etiologic role for H pylori infection on development of SCCL (chi(2) = 4.85, P< 0.05). CONCLUSION: H pylori infection of the upper aerodigestive tract might result in mucosal disruption, allowing for subsequent transformation by known carcinogens such as tobacco and alcohol.
机译：目的：幽门螺杆菌可引起慢性感染，这种感染与航空消化道良性和恶性疾病的发展有关。这项研究的目的是确定幽门螺杆菌感染与喉鳞状细胞癌（SCCL）之间的联系。方法：我们使用ELISA技术评估了26例SCCL患者和32例无喉癌的对照患者血清中针对幽门螺杆菌抗原的IgG抗体的存在。结果：SCCL患者血清阳性的发生率为73.07％，对照组为40.62％。这些数据支持幽门螺杆菌感染对SCCL发展的病因学作用（chi（2）= 4.85，P <0.05）。结论：幽门螺杆菌感染上消化道可能会导致粘膜破坏，随后可通过已知的致癌物如烟草和酒精进行转化。

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