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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo.
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Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo.

机译：姜黄素在体内抑制皮肤鳞状细胞癌肿瘤的生长。

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OBJECTIVE: Squamous cell carcinoma (SCCa) has increased from 4% to 10% over 4 decades, stimulating interest in developing novel agents that slow sun-damaged skin progression. This is the first study evaluating the naturally occurring bioactive food compound curcumin on skin cancer xenografts. Low bioavailability of curcumin has slowed its transition to clinical trials. It is hypothesized that curcumin has growth-inhibitory effects through the TOR pathway and chemopreventive potential in skin SCCa where local application could bypass bioavailability problems. STUDY DESIGN: A randomized experimental animal and laboratory study. SETTING: Louisiana State University Health Sciences Center, Shreveport, Louisiana. SUBJECTS AND METHODS: SCID mice were pretreated with 0, 5, or 15 mg of curcumin (n = 8 per group), 3 days prior to injecting 10 SRB12-p9 skin SCCa cells in each flank, and were gavaged daily thereafter. Tumor volumes were measured and tumors were harvested on day 24 when mice were sacrificed. Immunohistochemical analysis of pS6 expression (n = 3 per group) and tumor volumes in the 3 groups were compared using 1-way analysis of variance and pairwise comparisons were determined with the Tukey t test if overall comparisons were significant. RESULTS: Tumor volume increased 2.3 times faster in control mice compared with the group receiving 15 mg of curcumin (P = .0003). A significant difference in average tumor volumes was seen (P = .0012), especially with treatment of 15 mg of curcumin compared with control P = .0003). Curcumin inhibited S6 phosphorylation (P = .0027), suggest-ing inhibition of the MTOR pathway. CONCLUSION: Curcumin appears to inhibit skin SCCa growth and blocks tumor progression by inhibiting pS6 even when gavage is used to deliver curcumin, indicating even more significant effects in future experiments with local application.
机译：目的：鳞状细胞癌（SCCa）在过去的40年中已从4％增加到10％，激发了人们对开发能够减缓阳光伤害的皮肤进程的新型药物的兴趣。这是第一项评估天然存在的生物活性食物化合物姜黄素对皮肤癌异种移植物的研究。姜黄素的低生物利用度减慢了其向临床试验的过渡。据推测，姜黄素通过TOR途径具有抑制生长的作用，并在皮肤SCCa中具有化学预防的潜力，而局部应用可能会绕过生物利用度问题。研究设计：一项随机的实验动物和实验室研究。地点：路易斯安那州什里夫波特路易斯安那州立大学健康科学中心。研究对象和方法：在每侧腹腔注射10个SRB12-p9皮肤SCCa细胞之前3天，分别以0、5或15 mg姜黄素（每组n = 8）对SCID小鼠进行预处理，然后每天对其进行管饲。在处死小鼠的第24天，测量肿瘤体积并收获肿瘤。使用方差单向分析比较3组中pS6表达的免疫组织化学分析（每组n = 3）和肿瘤体积，如果总体比较显着，则采用Tukey t检验确定成对比较。结果：与接受15 mg姜黄素的组相比，对照组小鼠的肿瘤体积增加了2.3倍（P = .0003）。观察到平均肿瘤体积有显着差异（P = .0012），尤其是与对照P = .0003相比，治疗15 mg姜黄素的情况更是如此。姜黄素抑制S6磷酸化（P = 0.0027），表明抑制了MTOR途径。结论：姜黄素似乎通过抑制pS6抑制皮肤SCCa的生长并阻止肿瘤的进展，即使使用管饲法递送姜黄素也是如此，这表明在未来的局部应用实验中，其作用更为显着。

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