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首页> 外文期刊>Cerebral cortex >Timing and precision of spike initiation in layer V pyramidal cells of the rat somatosensory cortex.
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Timing and precision of spike initiation in layer V pyramidal cells of the rat somatosensory cortex.

机译：大鼠体感皮层V层锥体细胞中尖峰起始的时间和精度。

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摘要

The timing and location of action potential initiation in layer V pyramidal cells of the rat somatosensory cortex depends on different ligand-gated and intrinsic conductances. In order to assess the shunting effect of GABA(A) receptor activation and I(h) on the summative properties of these neurons, we recorded simultaneously from their somata and dendrites and induced combined excitatory and inhibitory postsynaptic potentials using extracellular stimulation. Three major consequences of GABA(A) receptor activation on the integration properties were found: (i) the action potential could be initiated in the distal apical dendrite, if GABA(A) receptors were simultaneously activated in the soma; (ii) GABA(A) receptor activation narrowed the time window for suprathreshold summation of two coincident excitatory synaptic inputs by a factor of 3.4; and (iii) uneven weights of the GABAergic components between two inputs could lead to unbalanced shunting and consequently to a time shift in the peak of the coincidence detection window. Blockade of I(h) practically abolished coincidence detection within a time window of 30 ms. Location of spike initiation and summation of coincident inputs in pyramidal cells is determined by at least two shunting mechanisms: activation of the presynaptic inhibitory network and modulation of I(h) as a function of the postsynaptic membrane potential.
机译：大鼠体感皮层的V层锥体细胞中动作电位启动的时机和位置取决于不同的配体门控和固有电导。为了评估GABA（A）受体激活和I（h）对这些神经元的累加特性的分流效果，我们同时记录了它们的躯体和树突，并使用细胞外刺激诱导了组合的兴奋性和抑制性突触后电位。发现了GABA（A）受体激活对整合特性的三个主要结果：（i）如果GABA（A）受体同时在躯体中被激活，则动作电位可以在远尖端的树突中启动。 （ii）GABA（A）受体的激活将两个同时发生的兴奋性突触输入的阈上求和的时间窗缩短了3.4倍; （iii）两个输入之间的GABA能成分的权重不均匀可能会导致不平衡的分流，从而导致巧合检测窗口的峰值出现时间偏移。 I（h）的封锁实际上取消了30毫秒时间范围内的重合检测。至少两个分流机制决定了锥体细胞中尖峰启动的位置和同时输入的总和：至少两个分流机制：突触前抑制网络的激活和作为突触后膜电位函数的I（h）的调节。

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