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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >Total antioxidant status and markers of oxidative stress in subjects with normal or impaired glucose regulation (IFG, IGT) in diabetic patients
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Total antioxidant status and markers of oxidative stress in subjects with normal or impaired glucose regulation (IFG, IGT) in diabetic patients

机译：糖尿病患者血糖调节正常或受损（IFG，IGT）的总抗氧化剂状态和氧化应激指标

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摘要

Background. We investigated the ischemia-modified albumin (IMA), advanced oxidation protein products (AOPPs), prooxidants-antioxidants balance (PAB), and ferric reducing antioxidant power (FRAP) concentrations in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) and compared the results to those of normoglycemic individuals at baseline and 2 hours after glucose loading. Methods. An oral glucose tolerance test was performed on age-matched subjects (n = 110) with a body mass index (BMI) < 27 kg/m. Subjects were categorized as normoglycemic (n = 35), IFG (n = 25), IGT (n = 30) and DM (n = 20) according to the WHO criteria. The IMA, AOPP, PAB, FRAP concentrations were determined by colorimetric methods. Results. At baseline, the AOPP concentrations were significantly higher in subjects with IFG and DM compared to normoglycemic subjects (p < 0.01 for all cases). The IFG, IGT and DM patients had a significantly higher IMA at baseline when compared with the normoglycemic individuals (p < 0.001 for all cases). The IMA in IFG subjects was significantly elevated (p < 0.05), while in DM patients, the IMA was significantly decreased (p < 0.001) after glucose loading with respect to baseline concentrations. Following glucose loading, the PAB was significantly decreased from baseline concentrations in normoglycemic individuals (p < 0.001) and in the IFG (p < 0.001) and IGT (p < 0.001) patients. Conclusion. In subjects with impaired glucose metabolism, the hyperglycemia is associated with increased IMA, AOPP and PAB concentrations. Increased IMA in subjects with IFG and decreased FRAP concentrations in subjects with IGT after glucose loading suggests that an increase in glucose concentrations can lead to tissue damage by increasing oxidative stress.
机译：背景。我们研究了空腹血糖受损（IFG），葡萄糖耐量受损（）的患者的缺血修饰白蛋白（IMA），高级氧化蛋白产物（AOPPs），促氧化剂-抗氧化剂平衡（PAB）和三价铁还原抗氧化能力（FRAP）浓度。 IGT）和糖尿病（DM），并将其与基线和血糖负荷后2小时的正常血糖个体的结果进行比较。方法。对年龄匹配的受试者（n = 110）的体重指数（BMI）<27 kg / m进行了口服葡萄糖耐量试验。根据WHO标准，将受试者分为正常血糖（n = 35），IFG（n = 25），IGT（n = 30）和DM（n = 20）。通过比色法测定IMA，AOPP，PAB，FRAP浓度。结果。基线时，IFG和DM患者的AOPP浓度明显高于血糖正常的患者（所有情况均p <0.01）。与血糖正常的个体相比，IFG，IGT和DM患者的基线IMA显着更高（所有病例的p <0.001）。 IFG受试者的IMA显着升高（p <0.05），而在DM患者中，相对于基线浓度，葡萄糖负荷后IMA显着降低（p <0.001）。葡萄糖负荷后，正常血糖患者（p <0.001）和IFG（p <0.001）和IGT（p <0.001）患者的PAB明显低于基线浓度。结论。在葡萄糖代谢受损的受试者中，高血糖症与IMA，AOPP和PAB浓度升高有关。葡萄糖负荷后，IFG受试者的IMA升高，IGT受试者的FRAP浓度降低，这表明葡萄糖浓度的升高可通过增加氧化应激而导致组织损伤。

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