ER protein quality control and proteasome-mediated protein degradation

Brodsky JL; McCracken AA

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ER protein quality control and proteasome-mediated protein degradation

机译：内质网蛋白质量控制和蛋白酶体介导的蛋白降解

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A variety of mutant polypeptides that are associated with human disease are targeted for degradation by an endoplasmic reticulum (ER) quality control system. In addition, physiological signals and viral gene products can target the degradation of several ER resident proteins and secreted proteins passing through the ER. Although the mechanism of protein quality control and the site of degradation were obscure, recent data indicate that degradation requires the cytosolic proteasome. Biochemical and genetic analyses have indicated that both lumenal and integral membrane proteins are selected for proteolysis and exported to the cytosol by a process that in several cases requires ER-associated molecular chaperones.

机译：内质网（ER）质量控制系统可靶向降解与人类疾病相关的多种突变多肽。另外，生理信号和病毒基因产物可以靶向几种内质网驻留蛋白和通过内质网的分泌蛋白的降解。尽管蛋白质质量控制的机制和降解位点不清楚，但最近的数据表明降解需要胞质蛋白酶体。生化和遗传分析表明，腔蛋白和整合膜蛋白均被选择进行蛋白水解，并通过一种在某些情况下需要与ER相关的分子伴侣的过程而输出到细胞质中。

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《Seminars in cell and developmental biology》 |1999年第5期|共7页
作者
Brodsky JL; McCracken AA;
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正文语种 eng
中图分类细胞生物学;
关键词
Protein turnover; Endoplasmic reticulum; Membrane proteins; Chaperones; Protein export; proteasomes;

机译：蛋白质更新;内质网;膜蛋白;伴侣蛋白;蛋白质输出;蛋白酶体;

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1. ER protein quality control and proteasome-mediated protein degradation [J] . Brodsky JL, McCracken AA Seminars in cell and developmental biology . 1999,第5期

机译：内质网蛋白质量控制和蛋白酶体介导的蛋白降解
2. Abnormal expression of ER quality control and ER associated degradation proteins in the dorsolateral prefrontal cortex in schizophrenia [J] . Kim Pitna, Scott Madeline R., Meador-Woodruff James H. Schizophrenia research . 2018,第期

机译：精神分裂症中背侧前额叶皮质中ER质量控制和ER相关降解蛋白的异常表达
3. Search and destroy: ER quality control and ER-associated protein degradation. [J] . Sayeed A, Ng DT Critical Reviews in Biochemistry and Molecular Biology . 2005,第2期

机译：搜索和销毁：ER质量控制和与ER相关的蛋白质降解。
4. Effects of dietary crude protein and ruminally-degradable protein on urea recycling and microbial protein production in beef heifers [C] . K. Baker, T. Mutsvangwa, J.J. McKinnon, International Symposium on Energy and Protein Metabolism and Nutrition . 2007

机译：膳食粗蛋白和uminally-可降解蛋白对牛仔母牛尿液回收和微生物蛋白产生的影响
5. Degradation signals for ubiquitin/proteasome-mediated cytosolic protein quality control. [D] . Maurer, Matthew J. 2012

机译：用于泛素/蛋白酶体介导的胞质蛋白质量控制的降解信号。
6. Abnormal Expression of ER Quality Control and ER Associated Degradation Proteins in the Dorsolateral Prefrontal Cortex in Schizophrenia [O] . Pitna Kim, Madeline R. Scott, James H. Meador-Woodruff -1

机译：精神分裂症患者背外侧前额叶皮层内质网质控及内质网相关降解蛋白的异常表达
7. Ubiquitin/proteasome-mediated protein degradation and quality control of misfolded proteins in the endoplasmic reticulum [O] . Tokunaga Fuminori, Kousaka Takao, Koide Takehiko 2001

机译：泛素/蛋白酶体介导的蛋白降解和内质网错折叠蛋白的质量控制

ER protein quality control and proteasome-mediated protein degradation

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