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首页> 外文期刊>Sexually Transmitted Infections >Susceptibilities of Neisseria gonorrhoeae to fluoroquinolones and other antimicrobial agents in Hyogo and Osaka, Japan.
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Susceptibilities of Neisseria gonorrhoeae to fluoroquinolones and other antimicrobial agents in Hyogo and Osaka, Japan.

机译：在日本兵库县和大阪市，淋病奈瑟氏球菌对氟喹诺酮类药物和其他抗菌剂的敏感性。

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OBJECTIVES: Decreasing susceptibility of Neisseria gonorrhoeae to fluoroquinolones has been reported in several countries. Knowledge of local N gonorrhoeae susceptibilities to various antimicrobials is important for establishing a rational treatment strategy in each region. METHODS: Isolates of N gonorrhoeae from male urethritis patients attending four urological clinics in Hyogo and Osaka prefectures in Japan were collected during 2002. The MICs for nine antimicrobials: penicillin G, tetracycline, cefixime, ceftriaxone, levofloxacin, gatifloxacin, ciprofloxacin, moxifloxacin, and spectinomycin were determined for each isolate. All isolates were also tested for beta lactamase producing profiles. RESULTS: Among the 87 isolates obtained, only one isolate was revealed to produce beta lactamase. MIC90 values for ciprofloxacin, levofloxacin, gatifloxacin, and moxifloxacin were over 8 microg/ml, over 8 microg/ml, 4 microg/ml, and 2 microg/ml, respectively. The proportion of isolates resistant to fluoroquinolones was over 60% (ciprofloxacin, 70.1%; levofloxacin, 65.5%; gatifloxacin, 70.1%). Chromosomally mediated penicillin and tetracycline resistance was identified in 12.6% and 33.3% of the isolates. MIC90 values for cefixime and ceftriaxone and were 0.5 microg/ml and 0.0063 microg/ml. All isolates were sensitive to ceftriaxone and 90.8% of them were sensitive to cefixime. MIC90 for spectinomycin was 32 microg/ml and all isolates were sensitive to it. Fluoroquinolone resistance correlated significantly with MICs for penicillin G but not tetracycline. CONCLUSION: Ceftriaxone and spectinomycin demonstrated lower MICs and so are recommended for N gonorrhoeae. Susceptibilities of N gonorrhoeae should be monitored periodically by region.
机译：目的：已有报道称淋病奈瑟氏球菌对氟喹诺酮类药物的敏感性下降。了解当地淋病奈瑟菌对各种抗生素的敏感性对于在每个地区建立合理的治疗策略都很重要。方法：2002年在日本兵库县和大阪府四所泌尿科门诊就诊的男性尿道炎患者中分离出淋病奈瑟菌。九种抗菌药物的MIC值：青霉素G，四环素，头孢克肟，头孢曲松酮，左氧氟沙星，加替沙星，环丙沙星，环丙沙星，环丙沙星，环丙沙星确定每种分离物的壮观霉素。还测试了所有分离物的β-内酰胺酶生产概况。结果：在获得的87株分离物中，只有1株被分离出可产生β-内酰胺酶。环丙沙星，左氧氟沙星，加替沙星和莫西沙星的MIC90值分别超过8微克/毫升，超过8微克/毫升，4微克/毫升和2微克/毫升。对氟喹诺酮类耐药的分离株比例超过60％（环丙沙星70.1％;左氧氟沙星65.5％;加替沙星70.1％）。染色体介导的青霉素和四环素耐药性在分离株中分别占12.6％和33.3％。头孢克肟和头孢曲松的MIC90值分别为0.5微克/毫升和0.0063微克/毫升。所有分离株对头孢曲松敏感，其中90.8％对头孢克肟敏感。壮观霉素的MIC90为32微克/毫升，所有分离株均对其敏感。氟喹诺酮耐药与青霉素G的MIC显着相关，而与四环素无关。结论：头孢曲松和壮观霉素显示较低的MIC，因此推荐用于淋病奈瑟氏球菌。应按地区定期监测淋病奈瑟菌的敏感性。

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