• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Seminars in pediatric infectious diseases >Coagulase-negative staphylococcal infections in the neonate and child: an update.
【24h】

Coagulase-negative staphylococcal infections in the neonate and child: an update.

机译：新生儿和儿童中凝固酶阴性葡萄球菌感染：最新情况。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Coagulase-negative staphylococcus (CONS) infection is the most common bloodstream infection treated in neonatal and pediatric intensive care units and significantly impacts patient mortality and morbidity. Staphylococcus epidermidis is the most common CONS species isolated clinically and investigated for its pathogenicity and virulence. Difficulties exist in the differentiation of CONS infection from culture contamination in clinical specimens, as CONS is a common skin commensal. Most CONS isolates have the mecA gene and exhibit beta-lactam resistance. The glycopeptide antibiotics, such as vancomycin, are the mainstay in therapy, although resistance has been reported. Arbekacin, linezolid, and streptogramins are newer antibiotics being evaluated as alternatives to glycopeptides. Monoclonal and polyclonal antibodies have been developed against the cell-wall components of staphylococcus and may hold promise for immune prophylaxis and treatment of CONS infection.
机译：凝固酶阴性葡萄球菌（CONS）感染是新生儿和儿科重症监护病房中最常见的血液感染，对患者的死亡率和发病率有重大影响。表皮葡萄球菌是临床上分离的最常见的CONS物种，并对其致病性和毒力进行了研究。由于CONS是常见的皮肤病，因此在临床标本中将CONS感染与培养物污染区分开来存在困难。大多数CONS分离株具有mecA基因，并表现出β-内酰胺抗性。糖肽类抗生素，例如万古霉素，是治疗的主要手段，尽管已经报道了耐药性。阿贝卡星，利奈唑胺和链霉菌素是较新的抗生素，正在被评估为糖肽的替代品。已针对葡萄球菌的细胞壁成分开发了单克隆和多克隆抗体，它们可能为免疫预防和CONS感染的治疗带来希望。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号