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Recent Developments in Paraneoplastic Disorders of the Nervous System

机译:神经系统副肿瘤性疾病的最新进展

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Paraneoplastic disorders of the nervous system (PNDs) are rare and unique disorders, where a specific pattern of neural damage occurs as a side effect of the interaction between the neoplasm and the host immune response. Clinical recognition of PNDs may be challenging but can lead to early detection of an occult neoplasm. Their study may lead to a better understanding of nervous system autoimmunity and even to devising novel immunotherapies against certain tumor types. Familiarity with the clinical syndromes, neuroradiological findings, autoantibodies, and tissue responses associated with PND may help arrive at a correct diagnosis in most cases.
机译:神经系统副肿瘤性疾病(PNDs)是罕见且独特的疾病,其中神经损伤的特定模式是肿瘤与宿主免疫反应之间相互作用的副作用。 PND的临床识别可能具有挑战性,但可能导致早期发现隐匿性肿瘤。他们的研究可能导致对神经系统自身免疫性的更好理解,甚至可以针对某些肿瘤类型设计出新颖的免疫疗法。熟悉与PND相关的临床综合征,神经放射学发现,自身抗体和组织反应可能有助于在大多数情况下进行正确的诊断。

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