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Hepatocellular Adenomas: WHO Classification and Immunohistochemical Workup.

机译:肝细胞腺瘤:WHO分类和免疫组织化学检查。

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This review discusses the various subtypes of hepatocellular adenomas (HCAs), their diagnosis, and management. HCAs are benign tumors, mostly seen in young women in a normal background liver. Recent advances in understanding HCA pathogenesis and molecular alterations led to recognition of different subtypes, now included in the WHO classification. Complications include hemorrhage and rarely malignant transformation into hepatocellular carcinoma. Diagnosis and differentiation are challenging, requiring careful attention to clinical setting, histology, and immuostaining profile. Risk of complications varies depending on the HCA; hence, subtyping has clinical significance and is performed based on morphology and use of selected immunohistochemical markers.
机译:这篇综述讨论了肝细胞腺瘤(HCA)的各种亚型,它们的诊断和治疗。 HCA是良性肿瘤,多数见于正常背景肝脏中的年轻女性。在了解HCA发病机理和分子改变方面的最新进展导致人们认识到了不同的亚型,这些亚型现已包括在WHO分类中。并发症包括出血,很少恶变为肝细胞癌。诊断和区分具有挑战性,需要仔细注意临床环境,组织学和染色不均。并发症的风险因HCA而异;因此,亚型分型具有临床意义,并基于形态学和所选免疫组化标记物的使用进行。

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