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首页> 外文期刊>Parasitology >Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1
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Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1

机译：小鼠染色体1上控制对面包酵母的抵抗力的基因的证据

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摘要

Resistance to infections with Heligmosomoides bakeri is associated with a significant quantitative trait locus (QTL-Hbnr1) on mouse chromosome 1 (MMU1). We exploited recombinant mice, with a segment of MMU1 from susceptible C57Bl/10 mice introgressed onto MMU1 in intermediate responder NOD mice (strains 1094 and 6109). BALB/c (intermediate responder) and C57Bl/6 mice (poor responder) were included as control strains and strain 1098 (B10 alleles on MMU3) as NOD controls. BALB/c mice resisted infection rapidly and C57Bl/6 accumulated heavy worm burdens. Fecal egg counts dropped by weeks 10-11 in strain 1098, but strains 1094 and 6109 continued to produce eggs, harbouring more worms when autopsied (day 77). PubMed search identified 3 genes (Ctla4, Cd28, Icos) as associated with Heligmosomoides' in the B10 insert. Single nucleotide polymorphism (SNP) differences in Ctla4 could be responsible for regulatory changes in gene function, and a SNP within a splice site in Cd28 could have an impact on function, but no polymorphisms with predicted effects on function were found in Icos. Therefore, one or more genes encoded in the B10 insert into NOD mice contribute to the response phenotype, narrowing down the search for genes underlying the H. bakeri resistance QTL, and suggest Cd28 and Ctla4 as candidate genes.
机译：对面包虫感染的抵抗力与小鼠1号染色体（MMU1）上的重要数量性状基因座（QTL-Hbnr1）相关。我们利用重组小鼠，将来自易感C57B1 / 10小鼠的一部分MMU1渗入中间应答NOD小鼠（菌株1094和6109）的MMU1中。包括BALB / c（中等应答者）和C57Bl / 6小鼠（应答者差）作为对照菌株，并包括菌株1098（MMU3上的B10等位基因）作为NOD对照。 BALB / c小鼠快速抵抗感染，C57Bl / 6积累了沉重的蠕虫负担。 1098株的粪便卵数下降了10-11周，但1094和6109株继续产卵，尸检时带有更多蠕虫（第77天）。 PubMed搜索确定了3个基因（Ctla4，Cd28，Icos）与B10插入物中的Heligmosomoides'相关。 Ctla4中的单核苷酸多态性（SNP）差异可能是基因功能的调节变化的原因，而Cd28剪接位点内的SNP可能对功能有影响，但在Icos中未发现对功能有预期影响的多态性。因此，在NOD小鼠的B10插入物中编码的一个或多个基因有助于响应表型，从而缩小了对面包酵母菌抗性QTL的基因的搜索范围，并建议Cd28和Ctla4作为候选基因。

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