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首页> 外文期刊>Parasitology >A case-controlled study of Dientamoeba fragilis infections in children
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A case-controlled study of Dientamoeba fragilis infections in children

机译：儿童脆弱性Dientamoeba感染的病例对照研究

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Dientamoeba fragilis is a pathogenic protozoan parasite that is implicated as a cause of human diarrhoea. A case-controlled study was conducted to determine the clinical signs associated with D. fragilis infection in children presenting to a Sydney Hospital. Treatment options are also discussed. Stool specimens were collected from children aged 1S years or younger and analysed for the presence of D. fragilis. In total, 41 children were included in the study along with a control group. Laboratory diagnosis was performed by microscopy of permanently stained, fixed faecal smears and by real-time PCR. Gastrointestinal symptoms were present in 40/41 (98%) of these children with dientamoebiasis, with diarrhoea (71%) and abdominal pain (29%) the most common clinical signs. Chronic gastrointestinal symptoms were present in 2% of cases. The most common anti-microbial used for treatment was metronidazole (n = 41), with complete resolution of symptoms and clearance of parasite occurring in 85% of cases. A treatment failure rate occurred in 15% of those treated with metronidazole. Follow-up treatment comprised of an additional course of metronidazole or iodoquinol was needed in order to achieve complete resolution of infection and symptoms in this group. This study demonstrates the pathogenic potential of D. fragilis in children and as such it is recommended that all laboratories must routinely test for this organism and treat if detected.
机译：脆弱的Dientamoeba是一种致病性的原生动物寄生虫，与人类腹泻有关。进行了一项病例对照研究，以确定在悉尼医院就诊的儿童中脆弱类杆菌感染的相关临床体征。还讨论了治疗方案。从1S岁或以下的儿童中收集粪便标本，并分析其是否存在脆弱的D. fragilis。总共有41名儿童与对照组一起被纳入研究。实验室诊断通过显微镜检查永久染色的固定粪便涂片并通过实时PCR进行。这些患肠病的儿童中有40/41（98％）出现胃肠道症状，其中最常见的临床症状是腹泻（71％）和腹痛（29％）。 2％的病例出现慢性胃肠道症状。用于治疗的最常见的抗菌药物是甲硝唑（n = 41），在85％的病例中可完全缓解症状并清除寄生虫。用甲硝唑治疗者中有15％出现治疗失败率。为了使该组患者的感染和症状得到完全缓解，需要进一步的甲硝唑或碘喹酚疗程的随访治疗。这项研究证明了脆弱小球藻的致病潜力，因此建议所有实验室必须常规检测这种微生物并在发现后进行治疗。

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