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首页> 外文期刊>Parasitology >Different protein of Echinococcus granulosus stimulates dendritic induced immune response
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Different protein of Echinococcus granulosus stimulates dendritic induced immune response

机译：细粒棘球oc不同蛋白刺激树突状免疫反应

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摘要

Cystic echinococcosis is a chronic infectious disease that results from a host/parasite interaction. Vaccination with ferritin derived from Echinococcus granulosus is a potential preventative treatment. To understand whether ferritin is capable of inducing a host immune response, we investigated the response of dendritic cells (DCs) to both recombinant ferritin protein and the hydatid fluid (HF) of E. granulosus. We evaluated the immunomodulatory potential of these antigens by performing, immunocytochemistry, electron microscopy and in vivo imaging of monocyte-derived murine DCs. During antigen stimulation of DCs, ferritin cause DCs maturation and induced higher levels of surface marker expression and activated T-cell proliferation and migration. On contrary, HF failed to induce surface marker expression and to stimulate T-cell proliferation. In response to HF, DCs produced interleukin-6 (IL-6), but no IL-12 and IL-10. DCs stimulated with ferritin produced high levels of cytokines. Overall, HF appears to induce host immunosuppression in order to ensure parasite survival via inhibits DC maturation and promotes Th2-dependent secretion of cytokines. Although ferritin also promoted DC maturation and cytokine release, it also activates CD4(+)T-cell proliferation, but regard of the mechanism of the Eg.ferritin induce host to eradicate E. granulosus were not clear.
机译：囊性棘球co病是一种由宿主/寄生虫相互作用引起的慢性感染性疾病。用源自细粒棘球oc的铁蛋白接种是一种潜在的预防性治疗。为了了解铁蛋白是否能够诱导宿主免疫应答，我们研究了树突状细胞（DC）对重组铁蛋白和粒状大肠杆菌的包虫液（HF）的响应。我们通过执行，免疫细胞化学，电子显微镜和单核细胞衍生的小鼠DC的体内成像评估了这些抗原的免疫调节潜力。在DC的抗原刺激过程中，铁蛋白导致DC成熟，并诱导较高水平的表面标志物表达以及活化的T细胞增殖和迁移。相反，HF未能诱导表面标志物表达并刺激T细胞增殖。响应HF，DC产生白介素6（IL-6），但没有IL-12和IL-10。用铁蛋白刺激的DC产生高水平的细胞因子。总体而言，HF似乎诱导宿主免疫抑制，以通过抑制DC成熟并促进Th2依赖性细胞因子分泌来确保寄生虫存活。尽管铁蛋白也促进DC成熟和细胞因子释放，但它也激活CD4（+）T细胞增殖，但关于铁蛋白诱导宿主根除大肠杆菌的机制尚不清楚。

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