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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Warts transmitted in families and schools: A prospective cohort
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Warts transmitted in families and schools: A prospective cohort

机译：家庭和学校传播的疣：一个预期的队列

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BACKGROUND AND OBJECTIVE: Cutaneous warts are common in primary schoolchildren; however, knowledge on the routes of transmission of human papillomavirus (HPV) causing warts is scarce. This study examines the association between the degree of HPV exposure and incidence of warts in primary schoolchildren to support evidence-based recommendations on wart prevention. METHODS: In this prospective cohort study, the hands and feet of all children in grades 1 to 7 (aged 4-12 years) of 3 Dutch primary schools were inspected for the presence of warts at baseline and after 11 to 18 months of follow-up. Data on the degree of HPV exposure included information obtained from parental questionnaires: preexistent warts, warts in family, prevalence of warts at baseline in the class, and use of public places (eg, swimming pools). RESULTS: Of the 1134 eligible children, 97% participated; the response rate from parental questionnaires was 77%, and loss to follow-up was 9%. The incidence for developing warts was 29 per 100 person-years at risk (95% confidence interval [CI] 26-32). Children with a white skin type had an increased risk of developing warts (hazard ratio [HR] 2.3, 95% CI 1.3-3.9). Having family members with warts (HR 2.08, 95% CI 1.52-2.86) and wart prevalence in the class (HR 1.20 per 10% increase, 95% CI 1.03-1.41) were independent environmental risk factors. CONCLUSIONS: The degree of HPV exposure in the family and school class contributes to the development of warts in schoolchildren. Preventive recommendations should focus more on limiting HPV transmission in families and school classes, rather than in public places.
机译：背景与目的：皮肤疣常见于小学生。但是，关于引起疣的人乳头瘤病毒（HPV）传播途径的知识很少。这项研究检查了小学生HPV暴露程度与疣发生率之间的关联，以支持基于证据的预防疣建议。方法：在这项前瞻性队列研究中，对荷兰3所小学的1至7年级（4至12岁）所有儿童的手脚进行了检查，在基线时以及随访11至18个月后检查是否存在疣。向上。关于HPV暴露程度的数据包括从父母调查表中获得的信息：既有疣，家庭疣，班级基线上的疣患病率以及公共场所（例如游泳池）的使用。结果：在1134名合格的儿童中，有97％的儿童参加了该项目。父母问卷的答复率为77％，随访损失为9％。患疣的风险为每100人年中有29人处于危险状态（95％置信区间[CI] 26-32）。皮肤白皙的儿童患疣的风险增加（危险比[HR] 2.3，95％CI 1.3-3.9）。家庭中有疣的家庭成员（HR 2.08，95％CI 1.52-2.86）和班级患病率（每增加10％HR 1.20，95％CI 1.03-1.41）是独立的环境危险因素。结论：家庭和学校班级中HPV暴露的程度有助于小学生疣的发展。预防性建议应更多地集中在限制家庭和学校课堂上的HPV传播，而不是在公共场所。

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