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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Susceptibility of XRCC3, XPD, and XPG genetic variants to cervical carcinoma.
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Susceptibility of XRCC3, XPD, and XPG genetic variants to cervical carcinoma.

机译：XRCC3，XPD和XPG遗传变异对宫颈癌的易感性。

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OBJECTIVE: DNA repair genes play a key role in maintaining genomic stability and integrity. DNA repair gene polymorphisms, such as those of XRCC3 and xeroderma pigmentosum, complementation group D and G (XPD, XPG), contribute to carcinogenesis. In this study, we investigated the correlation between cervical carcinoma risk and XRCC3, XPD, XPG genetic variants. METHODS: A case-control study of 400 cases including 200 carcinoma, 200 cervical intraepithelial neoplasia (CIN) and 200 normal women was performed. Four single nucleotide polymorphisms (SNPs) (XRCC3 Thr241Met, XPG His1104Asp, XPD Asp312Asn, and XPD Lys751Gln) were genotyped by mismatch amplification polymerase chain reaction. RESULTS: Women carrying homozygous Asp1104Asp genotypes had a significantly decreased risk of cervical or cervical squamous cell carcinoma compared to His1104Asp or His1104His genotypes. Similarly, XPD Asn312Asn (AA) reduced the risk of cervical or cervical squamous cell carcinoma. No association of XRCC3 Thr241Met or XPD Lys751Gln and cervical carcinoma was found. None of the 4 SNPs influenced the risk of CIN in our study. CONCLUSION: Our results support the hypothesis that genetic variations in DNA repair genes may contribute to an inherited genetic susceptibility to cervical carcinoma.
机译：目的：DNA修复基因在维持基因组稳定性和完整性中起着关键作用。 DNA修复基因多态性（例如XRCC3和色素干皮病），互补组D和G（XPD，XPG）有助于癌变。在这项研究中，我们调查了宫颈癌风险与XRCC3，XPD，XPG遗传变异之间的相关性。方法：对400例病例进行了病例对照研究，其中包括200例癌，200例宫颈上皮内瘤样变（CIN）和200例正常女性。通过错配扩增聚合酶链反应对四个单核苷酸多态性（SNP）（XRCC3 Thr241Met，XPG His1104Asp，XPD Asp312Asn和XPD Lys751Gln）进行基因分型。结果：与His1104Asp或His1104His基因型相比，携带纯合子Asp1104Asp基因型的妇女患宫颈或宫颈鳞状细胞癌的风险显着降低。同样，XPD Asn312Asn（AA）降低了子宫颈癌或子宫颈鳞状细胞癌的风险。没有发现XRCC3 Thr241Met或XPD Lys751Gln与宫颈癌的相关性。在我们的研究中，这4个SNP均未影响CIN的风险。结论：我们的研究结果支持以下假设：DNA修复基因的遗传变异可能导致子宫颈癌的遗传遗传易感性。

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