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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >The expression of thymidine phosphorylase suppresses spontaneous apoptosis of cancer cells in esophageal squamous cell carcinoma.
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The expression of thymidine phosphorylase suppresses spontaneous apoptosis of cancer cells in esophageal squamous cell carcinoma.

机译：胸苷磷酸化酶的表达抑制食管鳞状细胞癌癌细胞的自发凋亡。

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OBJECTIVE: Thymidine phosphorylase (TP) is an enzyme which converts thymidine to thymine. TP is expressed in a variety of human carcinomas and is known to be a potent angiogenic factor. A recent in vitro study indicated that TP is involved in the intracellular apoptotic signal transduction pathway. The aim of this study was to investigate the correlations between the expression of TP, microvessel density (MVD) and the occurrence of spontaneous apoptosis in esophageal squamous cell carcinoma (ESCC). METHODS: The expression of TP, intratumoral MVDs and percentages of apoptotic cancer cells, expressed by the apoptotic index (AI), of 155 tumors from 155 patients with ESCC were analyzed by immunohistochemistry and compared. RESULTS: Positive TP expression in cancer and stromal cells was detected in 89 (57.4%) and 104 (67.1%) cases, respectively. The mean MVD and mean AI of the 155 tumors were 288/mm(2) (range: 36-668/mm(2)) and 2.1% (range: 0-20.4%). The mean MVD of 104 tumors with TP-positive stromal cells (336/mm(2)) was higher than that of 51 tumors with TP-negative stromal cells (188/mm(2), p < 0.001). However, the mean MVD of 89 tumors with TP-positive cancer cells (293/mm(2)) did not differ from that of 66 tumors with TP-negative cancer cells (280/mm(2), p = 0.509). On the other hand, the mean AI of 89 tumors with TP-positive cancer cells (1.2%) was lower than that of 66 tumors with TP-negative cancer cells (3.4%, p < 0.001). However, the mean AI of 104 tumors with TP-positive stromal cells (1.9%) did not differ from that of 51 tumors with TP-negative stromal cells (2.6%, p = 0.058). No significant correlation between the MVDs and the AIs was observed (rho = -0.067, p = 0.409). CONCLUSION: In ESCC, TP may play an important role in tumor progression by increasing microvessels and suppressing apoptosis of cancer cells. Copyright 2001 S. Karger AG, Basel
机译：目的：胸苷磷酸化酶（TP）是一种将胸苷转化为胸腺嘧啶的酶。 TP在多种人类癌症中表达，并且已知是有效的血管生成因子。最近的一项体外研究表明，TP参与细胞内凋亡信号转导途径。这项研究的目的是调查食管鳞状细胞癌（ESCC）中TP的表达，微血管密度（MVD）与自发凋亡的发生之间的相关性。方法：采用免疫组织化学方法对155例ESCC患者的155例肿瘤的TP，肿瘤内MVD和凋亡细胞百分率进行表达分析。结果：分别在89例（57.4％）和104例（67.1％）病例中检测到了癌和基质细胞中TP阳性表达。 155个肿瘤的平均MVD和平均AI为288 / mm（2）（范围：36-668 / mm（2））和2.1％（范围：0-20.4％）。 TP阳性基质细胞的104个肿瘤的平均MVD（336 / mm（2））高于TP阴性基质细胞的51个肿瘤的平均MVD（188 / mm（2），p <0.001）。但是，具有TP阳性癌细胞的89个肿瘤的平均MVD（293 / mm（2））与具有TP阴性癌细胞的66个肿瘤的平均MVD（280 / mm（2），p = 0.509）没有差异。另一方面，TP阳性癌细胞的89个肿瘤的平均AI（1.2％）低于TP阴性癌细胞的66个肿瘤的平均AI（3.4％，p <0.001）。然而，具有TP阳性基质细胞的104个肿瘤的平均AI（1.9％）与具有TP阴性基质细胞的51个肿瘤的平均AI（2.6％，p = 0.058）没有差异。没有观察到MVD与AI之间的显着相关性（rho = -0.067，p = 0.409）。结论：在ESCC中，TP可能通过增加微血管和抑制癌细胞凋亡而在肿瘤进展中发挥重要作用。版权所有2001 S. Karger AG，巴塞尔

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