• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Imaging of aortic atherosclerotic lesions by (125)I-LDL, (125)I-oxidized-LDL, (125)I-HDL and (125)I-BSA.
【24h】

Imaging of aortic atherosclerotic lesions by (125)I-LDL, (125)I-oxidized-LDL, (125)I-HDL and (125)I-BSA.

机译：通过（125）I-LDL，（125）I氧化LDL，（125）I-HDL和（125）I-BSA对主动脉粥样硬化病变进行成像。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The aim of the present study was to compare the accumulation of (125)I-labeled low-density lipoproteins (LDL), oxidized LDL (oxLDL), HDL and BSA in advanced atherosclerotic lesions of apoE-deficient mice. METHODS: (125)I-lipoproteins or (125)I-BSA were injected into the tail vein of apoE-deficient mice. Blood clearance of (125)I-lipoproteins and (125)I-BSA and their accumulation in atherosclerotic lesions were assayed. RESULTS: Blood clearance of (125)I-LDL and (125)I-HDL was moderate, and approximately 30% of the injected lipoproteins were present in plasma 24 h following injection. oxLDL was removed much faster from plasma, and less than 10% of (125)I-oxLDL was present in the circulation 30 min after (125)I-oxLDL injection. The clearance of (125)I-BSA from the circulation was slower than the lipoprotein clearance. The highest accumulation of LDL, oxLDL, HDL and BSA was detected in atherosclerotic lesions in the aortic arch and abdominal aorta, while lower accumulation was detected in the less atherosclerotic descending thoracic aorta. CONCLUSION: Our findings demonstrate that both (125)I-HDL and (125)I-BSA as well as (125)I-LDL are accumulated in atherosclerotic plaques and that they can be used for the detection of atherosclerotic lesions. Copyright 2002 S. Karger AG, Basel
机译：目的：本研究的目的是比较（125）I标记的低密度脂蛋白（LDL），氧化型LDL（oxLDL），HDL和BSA在apoE缺陷小鼠的晚期动脉粥样硬化病变中的蓄积。方法：将（125）I-脂蛋白或（125）I-BSA注射到apoE缺陷小鼠的尾静脉中。测定（125）I-脂蛋白和（125）I-BSA的血液清除率及其在动脉粥样硬化病变中的蓄积情况。结果：（125）I-LDL和（125）I-HDL的血液清除率中等，注射后24小时血浆中约有30％的注射脂蛋白存在。从血浆中去除oxLDL的速度要快得多，并且在注射（125）I-oxLDL 30分钟后的循环中，不到10％的（125）I-oxLDL存在。 （125）I-BSA从循环中的清除比脂蛋白清除慢。在主动脉弓和腹主动脉的动脉粥样硬化病变中，LDL，oxLDL，HDL和BSA的积累最高，而在动脉粥样硬化的降主动脉中则发现较低的积累。结论：我们的研究结果表明（125）I-HDL和（125）I-BSA以及（125）I-LDL都积聚在动脉粥样硬化斑块中，可用于检测动脉粥样硬化病变。版权所有2002 S. Karger AG，巴塞尔

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号