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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Selective serotonin reuptake inhibitors may enhance responses to noxious stimulation.
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Selective serotonin reuptake inhibitors may enhance responses to noxious stimulation.

机译：选择性5-羟色胺再摄取抑制剂可增强对有害刺激的反应。

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摘要

The acute effects of various doses of two selective serotonin reuptake inhibitors (fluoxetine and fluvoxamine) on thermal and electrical stimulation-induced pain were investigated in drug-naive Wistar rats. The hot-plate and the tail-flick test and the noxious-induced withdrawal test were used. The two drugs had no effects on heat-induced pain behavior. However, the two compounds enhanced the motor responses induced by noxious electrical stimulation. These data contrast to what is generally found for tricyclic antidepressants and suggest a modality specific pain system. Cardiac and blood pressure were also found to change, but these changes were not correlated to changes in nociception. Taken together, the data suggest that the acutely administered selective serotonin reuptake inhibitors may exacerbate an acute type of pain.
机译：在未经药物治疗的Wistar大鼠中研究了各种剂量的两种选择性5-羟色胺再摄取抑制剂（氟西汀和氟伏沙明）对热和电刺激诱发的疼痛的急性作用。使用热板和甩尾试验以及有毒诱导的戒断试验。两种药物对热致疼痛行为无影响。但是，这两种化合物增强了有毒电刺激诱导的运动反应。这些数据与通常发现的三环类抗抑郁药形成鲜明对比，并暗示了一种模态特异性疼痛系统。还发现心脏和血压发生变化，但这些变化与伤害感受的变化无关。两者合计，数据表明急性施用的选择性5-羟色胺再摄取抑制剂可能会加剧急性疼痛。

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