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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis.
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Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis.

机译：蓖麻碱的药理学评价，蓖麻碱是从蓖麻中分离出来的中枢神经系统兴奋剂。

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The extract of the pericarp of castor bean (Ricinus communis) showed some typical central nervous system stimulant effects when administered to mice. The animals became exophthalmic, presented tremors and clonic seizures and died a few minutes after receiving larger doses of the extract. At lower doses the extract improved memory consolidation and showed some neuroleptic-like properties, such as a decrease in exploratory behavior and catalepsy. The memory-improving effect and the seizure-eliciting properties of the extract were also observed with the administration of ricinine, a neutral alkaloid isolated from the extract. However, the neuroleptic-like properties of the extract were not observed with ricinine. As the therapeutic index of ricinine is of the order of 200, the compound may be considered as a promising cognition-enhancing drug that may be used for the treatment of human amnesias.
机译：给予小鼠的蓖麻子（Ricinus communis）的果皮提取物表现出一些典型的中枢神经系统刺激作用。接受大剂量提取物后，动物眼球突出，出现震颤和阵挛性癫痫发作并死亡。在较低剂量下，提取物可改善记忆力，并表现出一些类似精神安定药的特性，例如探索行为和僵直症的减少。通过施用蓖麻碱，从提取物中分离出的中性生物碱，也观察到了提取物的记忆改善作用和引起癫痫发作的特性。然而，用蓖麻碱未观察到提取物的抗精神病药样性质。由于蓖麻碱的治疗指数约为200，因此该化合物可以被认为是一种有前途的认知增强药物，可以用于治疗人类健忘症。

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