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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acetylcholine release in ventral tegmental area by hypothalamic self-stimulation, eating, and drinking.
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Acetylcholine release in ventral tegmental area by hypothalamic self-stimulation, eating, and drinking.

机译：下丘脑自我刺激，进食和饮水会在腹侧被盖区释放乙酰胆碱。

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摘要

Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self-stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self-stimulation and ingestive behavior.
机译：提供了将乙酰胆碱（ACh）输入到中脑腹侧被盖区（VTA）的证据，作为自我刺激和摄食行为系统的一部分。雄性大鼠准备了一个电极，在下丘脑外侧丘脑和一个同侧的引导轴用于VTA中的微透析。在自我刺激，自动刺激，进食或饮水期间，VTA中的细胞外ACh升高。通过微透析探针将阿托品注入VTA足以阻止自我刺激并减少食物摄入。结论是，ACh在VTA中的毒蕈碱受体上起作用，是调节下丘脑自我刺激和摄食行为的回路的一部分。

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