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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Fentanyl self-administration in juvenile rats that were tolerant and dependent to fentanyl as infants.
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Fentanyl self-administration in juvenile rats that were tolerant and dependent to fentanyl as infants.

机译：芬太尼在婴儿中的耐受性并依赖于芬太尼的幼年大鼠自我给药。

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Human neonates and infants can become tolerant and dependent during continuous fentanyl or morphine administration. The long-term consequences in these individuals as juveniles and adults are unknown. This study compared fentanyl self-administration behavior in juvenile rats that were opioid naive or were exposed chronically to fentanyl as infants. Postnatal day 14 infant rats remained naive or were implanted with saline- or fentanyl-filled Alzet minipumps. After 72 h, fentanyl's antinociceptive potency was 3.0-fold lower in the fentanyl-infused rats. Naloxone precipitated withdrawal occurred only in the fentanyl-infused animals. Other similarly treated infant rats were allowed to mature into P42 juvenile rats before enrolling them in an oral fentanyl self-administration study. Rats from each group consumed significantly more fentanyl than quinine. However, those rats, tolerant and dependent to fentanyl as infants, did not self-administer more fentanyl than their opiate-naive littermates. The issue of whether fentanyl was consumed for its reinforcing properties was demonstrated when noncontingent administration of opiate antagonists significantly reduced fentanyl intake in another group of juvenile rats. These data indicate that fentanyl is consumed for its reinforcing properties, but that infant fentanyl tolerance and dependence did not predispose them to self-administer more fentanyl than opiate-naive animals.
机译：在连续服用芬太尼或吗啡期间，人类新生儿和婴儿可能会变得宽容和依赖。这些青少年和成年人的长期后果尚不清楚。这项研究比较了幼稚的阿片类药物或长期作为婴儿接触芬太尼的幼年大鼠的芬太尼自我给药行为。出生后第14天的幼鼠仍处于幼稚状态，或植入了充满盐水或芬太尼的Alzet微型泵。 72小时后，在注入芬太尼的大鼠中，芬太尼的抗伤害力降低了3.0倍。纳洛酮沉淀的戒断仅在输注芬太尼的动物中发生。在将其他接受相似治疗的婴儿大鼠纳入口服芬太尼自我管理研究之前，允许它们成熟为P42幼年大鼠。每组大鼠的芬太尼消耗量比奎宁明显多。但是，那些能忍受并依赖婴儿芬太尼的大鼠并未比未使用鸦片剂的同窝幼仔自我给药更多的芬太尼。非鸦片类鸦片拮抗剂的非暂时性给药显着降低了另一组幼年大鼠的芬太尼摄入量，这证明了芬太尼是否被消耗以增强其功能。这些数据表明食用芬太尼是因为其具有增强作用，但婴儿芬太尼的耐受性和依赖性并未使他们比未使用鸦片剂的动物更容易自我施用更多的芬太尼。

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