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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol flavor preference conditioned by intragastric carbohydrate in rats.
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Ethanol flavor preference conditioned by intragastric carbohydrate in rats.

机译：大鼠胃内碳水化合物对乙醇风味的偏爱。

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摘要

The unpalatable flavor of ethanol solutions greater than approximately 6% may limit their consumption by rats. We determined if ethanol flavor avoidance, like bitter or sour taste avoidance, can be reversed by intragastric (IG) carbohydrate conditioning. Ad lib fed rats drank 5% ethanol and a matched flavor (0.05% citric acid+0.5% maltodextrin, CM) on alternate days. For control rats, postingestive effects were equated: when they drank one solution they were infused IG with the other. Conditioned rats were also infused with 5% ethanol when they drank CM, but when they drank 5% ethanol they were infused with CM + 16% maltodextrin, a potent reward in flavor preference learning. In choice tests, only the conditioned rats preferred ethanol to CM; both groups preferred 5% ethanol to water. Conditioned rats but not controls preferred ethanol to water when the concentration was raised to 10%, and sustained their preference when the infusate carbohydrate was gradually removed. When ethanol concentration was gradually raised to 25%, ethanol preference declined from 48% to 30% in the control rats and from 84% to 50% in the conditioned rats. Thus, ethanol flavor avoidance can be reversed or reduced by postingestive nutritive conditioning, which may combine with the pharmacological effects of ethanol to produce the acquired appetite for the flavor of alcoholic beverages.
机译：大于6％的乙醇溶液难吃的味道可能会限制大鼠的食用。我们确定了避免乙醇味道（如避免苦味或酸味）可以通过胃内（IG）碳水化合物调理来逆转。随意喂养的大鼠在隔天喝5％的乙醇和相称的口味（0.05％柠檬酸+ 0.5％麦芽糖糊精，CM）。对于对照大鼠，其后消极作用是等同的：当他们喝一种溶液时，将它们与另一种溶液一起灌输IG。饮用CM时，也给条件正常的大鼠注入5％的乙醇，但是当饮用5％乙醇时，则注入CM + 16％的麦芽糊精，这是对风味偏好学习的有力奖励。在选择测试中，仅条件大鼠比乙醇更喜欢乙醇。两组都比水中使用5％的乙醇。当浓度增加到10％时，条件良好的大鼠而非乙醇优先选择乙醇而不是水，并在逐渐去除输注性碳水化合物时维持其偏爱。当乙醇浓度逐渐提高到25％时，对照组大鼠的乙醇偏爱率从48％降至30％，而条件大鼠的乙醇偏爱率则从84％降至50％。因此，可以通过后期营养调理来逆转或减少避免乙醇风味的方法，后者可以与乙醇的药理作用相结合，以产生对酒精饮料风味的食欲。

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