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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reinforcing effects of the neurosteroid allopregnanolone in rats.
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Reinforcing effects of the neurosteroid allopregnanolone in rats.

机译：神经甾体去甲泼尼龙对大鼠的增强作用。

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The GABA(A) receptor positive modulator allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) is a potent neurosteroid with behavioral and biochemical characteristics similar to ethanol, barbiturates, and benzodiazepines. This suggests that neurosteroids may provide an alternative class of sedative/hypnotic, anticonvulsant, and anxiolytic pharmacotherapies. However, there is evidence from animal models that neurosteroids may be susceptible to abuse by humans. Thus, the present study evaluated the reinforcing effects of orally administered allopregnanolone in rats. In the first experiment, male Long-Evans rats (n=9) were allowed to voluntarily consume a 50-microg/ml allopregnanolone (50A) solution or water in an unlimited-access two-bottle choice procedure for 10 days. Subsequently, the same animals were trained to lever-press to receive a 50A solution in daily 30-min operant sessions using a sucrose substitution procedure. In the two-bottle choice procedure, rats consumed significantly more allopregnanolone than water, suggesting that allopregnanolone was serving as a reinforcer. In the operant self-administration procedure, allopregnanolone did not maintain levels of responding that were different from water, suggesting that allopregnanolone did not function as a reinforcer in this procedure. These results suggest that orally administered allopregnanolone possesses reinforcing properties; however, additional studies are necessary to determine whether operant oral self-administration will be a viable index of allopregnanolone's reinforcing effects.
机译：GABA（A）受体阳性调节剂allopregnanolone（3alpha-hydroxy-5alpha-pregnan-20-one）是一种强效的神经甾体，具有类似于乙醇，巴比妥酸盐和苯并二氮杂卓的行为和生化特征。这表明神经固醇可能提供另一类镇静/催眠药，抗惊厥药和抗焦虑药治疗。但是，从动物模型中得出的证据表明，神经固醇可能易于被人类滥用。因此，本研究评估了口服阿洛培那诺酮对大鼠的增强作用。在第一个实验中，雄性Long-Evans大鼠（n = 9）被允许在无限制进入的两瓶选择程序中自愿摄入50微克/毫升的Allopregnanolone（50A）溶液或水，持续10天。随后，使用蔗糖替代程序，在每天30分钟的操作过程中，对相同的动物进行杠杆压制以接受50A溶液的训练。在两瓶选择程序中，大鼠消耗的Allopregnanolone明显多于水，这表明Allopregnanolone可以作为补强剂。在操作性自我给药程序中，Allopregnanolone不能维持与水不同的反应水平，这表明Allopregnanolone在该程序中没有起到增强作用。这些结果表明口服阿洛培那那龙酮具有增强作用。但是，还需要进行更多的研究来确定口服口服自我给药是否是阿洛培那诺酮增强作用的可行指标。

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