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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effect of Rhazya stricta Decne, a traditional medicinal plant, on spontaneous and drug-induced alterations in activity of rats.
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The effect of Rhazya stricta Decne, a traditional medicinal plant, on spontaneous and drug-induced alterations in activity of rats.

机译：传统药用植物严格生根对大鼠活动的自发和药物诱导的变化的影响。

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摘要

The effect of acute and chronic treatment of rats with a lyophilized extract of the leaves of the medicinal plant Rhazya stricta on total and ambulatory activity was studied. Given acutely at single oral doses of 1, 2, 4, and 8 g/kg, the extract produced dose-dependent decreases in total activity and ambulatory activity. Diazepam (20 mg/kg, orally) produced a decrease in rat activity comparable to that produced by a dose of 1 g/kg of the extract. When given daily at an oral dose of 2 g/kg for 21 consecutive days, the extract produced, on the last day of treatment, significant decrease in activity amounting to about 30% of control activity levels. Subcutaneous (SC) treatment of rats with caffeine (7.5, 15, and 30 mg/kg), dose-dependently and significantly increased total activity and ambulatory activity. These effects were dose-dependently attenuated when the extract was given concomitantly with caffeine at oral doses of 1, 2, and 4 mg/kg. Treatment of rats with zoxazolamine alone (10, 20, or 40 mg/kg, SC) or R. Stricta (1 and 4 g/kg orally) alone significantly decreased total and ambulatory activities. Concomitant treatment with zoxazolamine and R. Stricta decreased the rats activity to a greater degree than with either treatment given alone.
机译：研究了用药用植物生根豆叶片的冻干提取物对大鼠的急慢性治疗对总活动能力和动态能力的影响。分别以1、2、4和8 g / kg的单次口服剂量急性给予时，提取物的总活性和非卧床活性均呈剂量依赖性降低。地西p（20 mg / kg口服）可使大鼠活性降低，与剂量为1 g / kg的提取物所产生的降低相当。当每天以2 g / kg的口服剂量连续21天服用时，在治疗的最后一天，提取物产生的活性显着下降，约占对照活性水平的30％。用咖啡因（7.5、15和30 mg / kg）对大鼠进行皮下（SC）处理，剂量依赖性地显着增加了总活性和非卧床活动。当提取物与咖啡因同时口服，1、2和4 mg / kg时，这些作用随剂量而减弱。单独使用唑沙唑胺（10、20或40 mg / kg，SC）或单独使用R. Stricta（口服1和4 g / kg）治疗大鼠，可显着降低总活动能力。与单独给予任一治疗相比，佐沙唑胺和R. Stricta的同时治疗降低了大鼠的活动程度。

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