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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.
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The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.

机译：乙醇和可卡因及其组合对小鼠的致死作用：对可卡乙烯形成的影响。

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The HS line of mice was used to determine the LD50 values for cocaine and ethanol, as well as for cocaethylene, the enzymatic product of their coadministration. The LD50 of cocaethylene was found to be significantly lower than that of cocaine, and both were more potent in their lethality than ethanol. When a low-lethality dose of cocaine was administered with a nonlethal dose of ethanol, the result was a significant increase in the prevalence of lethality. Thus, the lethal effects of the dose of cocaine used were increased by the dose of ethanol administered such that the two drugs in combination were equipotent to cocaethylene. The results are discussed in light of the ability of the liver, via transestification, to rapidly form cocaethylene from cocaine in addition to ethanol's ability to decrease the catabolism of cocaine. Thus, the possibility exists that the increased lethality observed is produced by both the production of the more lethal cocaethylene and sustained levels of cocaine.
机译：小鼠的HS系用于测定可卡因和乙醇以及可卡因乙烯（它们共同给药的酶促产物）的LD50值。发现可卡乙烯的LD50显着低于可卡因，并且两者的致死性均比乙醇强。当将低致死剂量的可卡因与非致死剂量的乙醇一起使用时，其结果是致死率显着增加。因此，所用可卡因剂量的致死作用通过所施用的乙醇剂量而增加，使得两种药物的组合对等价于可卡乙烯。根据肝脏通过转座作用从可卡因迅速形成可卡乙烯的能力以及乙醇降低可卡因分解代谢的能力，对结果进行了讨论。因此，存在这样的可能性，即观察到增加的致死性是通过生产更具致死性的可卡因和持续保持可卡因水平而产生的。

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