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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of SCH39166 and domperidone on the meal patterning of male rats.
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Effects of SCH39166 and domperidone on the meal patterning of male rats.

机译：SCH39166和多潘立酮对雄性大鼠进食模式的影响。

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摘要

In male rats given free access to food (45 mg pellets) and water, ingestive behavior is structured into meals. The selective dopamine D1 antagonist SCH39166 had little effect on total food intake, meal size, or feeding rate. However, it did produce a marked, dose-related reduction in drinking that resulted from an increase in intermeal interval with unchanged meal size. Possible peripheral and central explanations of this effect are discussed. In a second experiment, the peripheral dopamine D2 antagonist, domperidone, was shown to have little effect on either feeding or drinking. A dose of 10 mg/kg did reduce feeding rate, but this probably represents a central effect, because doses that were only slightly higher have previously been shown to reduce stimulant-induced hyperactivity and stereotypy. These experiments confirm the functional distinction between D1-like and D2-like dopamine receptors in the control of ingestive behavior, with the D1 receptor having a greater role in drinking and central D2 receptors affecting several aspects of feeding behavior.
机译：在自由摄取食物（45毫克颗粒）和水的雄性大鼠中，进食行为被安排成进餐。选择性多巴胺D1拮抗剂SCH39166对总食物摄入量，进餐量或进食速度影响很小。但是，它确实导致了饮酒量的显着减少，这是由于进餐间隔增加而进餐量不变而导致的饮酒量减少。讨论了对此影响的可能的外围和中心解释。在第二个实验中，显示外周多巴胺D2拮抗剂多潘立酮对喂养或饮水几乎没有影响。 10 mg / kg的剂量确实会降低进食速度，但这可能代表了中心作用，因为以前仅显示出稍高的剂量会减少兴奋剂引起的过度活跃和陈规定型观念。这些实验证实了D1类和D2类多巴胺受体在控制饮食行为方面的功能区别，其中D1受体在饮酒中起更大作用，而中枢D2受体影响进食行为的多个方面。

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