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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Diurnal rhythms of paraventricular hypothalamic norepinephrine and food intake in rats.
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Diurnal rhythms of paraventricular hypothalamic norepinephrine and food intake in rats.

机译：大鼠心室下丘脑去甲肾上腺素的昼夜节律和食物摄入。

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摘要

Extracellular levels of endogenous norepinephrine (NE) within rat paraventricular hypothalamus (PVN) vary across the diurnal cycle, with a peak in NE level noted at the onset of the dark cycle, at which time feeding occurs in a burst. The present experiment further examined the relationship between food intake and extracellular levels of NE within the PVN and within sites located outside of the hypothalamus. Adult male rats were implanted with concentric microdialysis probes aimed at either the PVN or brain sites outside the PVN. Measures of food intake and of extracellular NE were collected every hour over a 24-h period. Rats with PVN probes exhibited two peaks in extracellular NE. The first peak in PVN NE occurred within 1 h before the onset of the dark phase (ZT11) and was significantly correlated (p < 0.02) with a marked burst of feeding during the first hour of the dark phase. In addition, a second NE peak occurred 8 h into the dark phase (ZT19) but was not accompanied by feeding. Rats bearing non-PVN probes did not exhibit alterations in extracellular NE yet did show a pattern of feeding similar to that noted in the PVN rats. These data support the hypothesis that the burst of feeding evident at the onset of dark is related, in part, to an increase in PVN extracellular NE.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：大鼠心室下丘脑下丘脑（PVN）中内源性去甲肾上腺素（NE）的细胞外水平在整个昼夜周期中变化，在黑暗周期开始时出现NE水平的峰值，这时爆发性进食。本实验进一步检查了食物摄入量与PVN以及下丘脑外侧部位内NE的胞外水平之间的关系。成年雄性大鼠植入针对PVN或PVN外部大脑部位的同心微透析探针。在24小时内每小时收集一次食物摄入量和细胞外NE的测量值。带有PVN探针的大鼠在细胞外NE中显示两个峰。 PVN NE的第一个高峰出现在黑暗阶段（ZT11）开始之前的1小时内，并且与黑暗阶段的第一个小时的进食明显爆发显着相关（p <0.02）。此外，第二个NE高峰出现在黑暗期（ZT19）的8小时内，但未伴有进食。携带非PVN探针的大鼠在细胞外NE上没有表现出改变，但确实表现出与PVN大鼠类似的进食模式。这些数据支持这样的假设，即在黑暗开始时明显的进食爆发部分与PVN细胞外NE的增加有关。（摘要截断为250个字）

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