DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities.

Meyer ME; McLaurin BI; Meyer ME

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DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities.

机译：DALDA（H-Tyr-D-Arg-Phe-Lys-NH2）是一种强效的阿片类肽激动剂，会影响运动活动的各种模式。

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The central effects of mu-opioid receptor agonist DALDA (ICV 0.00, 0.1, or 1.0 micrograms) were investigated in rats for 120 min on activity monitors. The durations in seconds of horizontal movement time, rearing time, and stereotypy time were measured during 12 consecutive 10-min time blocks. DALDA (ICV, 0.1 and 1.0 micrograms) resulted in biphasic effects, inhibition followed by activation for horizontal movement, rearing, and stereotypy times.

机译：在活动监视器上，在大鼠中研究了阿片类阿片受体激动剂DALDA（ICV 0.00、0.1或1.0微克）的主要作用120分钟。在12个连续的10分钟时间段内测量了水平移动时间，饲养时间和定型时间的秒数。 DALDA（ICV，0.1和1.0微克）产生双相效应，抑制后被激活以进行水平移动，饲养和定型时间。

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《Pharmacology, Biochemistry and Behavior》 |1995年第1期|共3页
作者
Meyer ME; McLaurin BI; Meyer ME;
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正文语种 eng
中图分类药理学;
关键词
Analgesics; Locomotion; Oligopeptides; Receptors; Opioid; mu; tyrosyl arginyl phenylalanyl lysinamide; 镇痛药; 行走; 寡肽类; 受体; 阿片样; μ;

机译：Analgesics;Locomotion;Oligopeptides;Receptors;Opioid;mu;tyrosyl arginyl phenylalanyl lysinamide;镇痛药;行走;寡肽类;受体;阿片样;μ;

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1. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. [J] . Meyer ME, McLaurin BI, Meyer ME Pharmacology, Biochemistry and Behavior . 1995,第1期

机译：DALDA（H-Tyr-D-Arg-Phe-Lys-NH2）是一种强效的阿片类肽激动剂，会影响运动活动的各种模式。
2. Pharmacological characterization of the dermorphin analog (Dmt(1))DALDA, a highly potent and selective mu-opioid peptide. [J] . Neilan CL, Nguyen TM, Schiller PW, European Journal of Pharmacology: An International Journal . 2001,第1期

机译：dermorphin类似物（Dmt（1））DALDA的药理学表征，这是一种高效且选择性的μ阿片肽。
3. Potent mu-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation [J] . Li Yangmei, Cazares Margret, Wu Jinhua, Journal of Medicinal Chemistry . 2016,第3期

机译：环状肽Tyr-c [D-Lys-Xxx-Tyr-Gly]的强μ阿片受体激动剂：合成，生物学和结构评价。
4. Effects of Methyl and Halogens in Analgesic Peptide Molecules for Their Potent Agonist Activities at MOR/DOR and Antagonist Activity at NK1R [C] . Aswini Kumar Giri, C.R. Apostol, P. Davis American Peptide Symposium . 2015

机译：镇痛肽分子在镇痛肽分子中甲基和卤素的影响Mor / Dor和NK1R拮抗剂活性的活性激动剂活性
5. Agonist-dependent mechanism of mu-opioid receptor desensitization. [D] . Chu, Ji. 2009

机译：mu阿片受体脱敏的激动剂依赖性机制。
6. Differential Analgesic Effects of a Mu-Opioid Peptide Dmt1DALDA and Morphine [O] . Megumi Shimoyama, Hazel H. Szeto, Peter W. Schiller, -1

机译：阿片类阿片肽Dmt1 DALDA和吗啡的镇痛差异
7. Differential Analgesic Effects of a Mu-Opioid Peptide, [Dmt1]DALDA, and Morphine [O] . Shimoyama, Megumi, Szeto, Hazel H., Schiller, Peter W., 2009

机译：阿片类阿片肽，[Dmt1] DALDA和吗啡的镇痛差异
8. Dehydroepiandrosterone Derivatives as Potent Antiandrogens with Marginal Agonist Activity. [R] . Miyamoto, H. 2015

机译：脱氢表雄酮衍生物作为具有边缘激动剂活性的强效抗雄激素。

DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities.

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