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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin.
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Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin.

机译：3,4-亚甲基二氧基甲基苯丙胺（MDMA）对海马多巴胺和血清素的影响。

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摘要

The 3,4-methylenedioxymethamphetamine (MDMA)-induced increase in the extracellular concentration of dopamine and the long-term depletion of 5-HT were studied in the hippocampus of the rat brain. MDMA produced a dose-dependent increase in the extracellular concentration of dopamine in the hippocampus, as well as in the striatum. The MDMA-induced increase in the extracellular concentration of dopamine in the hippocampus, but not in the striatum, was suppressed in rats treated with the norepinephrine uptake inhibitor, desipramine, and in rats in which noradrenergic neurons in the hippocampus were lesioned with DSP4 (N-(2- chloroethyl)-N-ethyl-2-bromo benzylamine). However, the long-term depletion of 5-HT in the hippocampus produced by MDMA was unaltered in desipramine-treated rats. These results are supportive of the view that the MDMA-induced increase in the extracellular concentration of dopamine in the hippocampus is the result of an enhanced release of dopamine from noradrenergic neurons. In addition, the MDMA-induced depletion of 5-HT in the hippocampus appears not to involve dopamine-initiated processes, because suppression of MDMA-induced dopamine release did not attenuate the long-term depletion of 5-HT in the hippocampus.
机译：在大鼠大脑海马中研究了3,4-亚甲基二氧基甲基苯丙胺（MDMA）诱导的细胞外多巴胺浓度增加和5-HT的长期耗竭。 MDMA在海马以及纹状体中使细胞外多巴胺浓度呈剂量依赖性增加。用去甲肾上腺素摄取抑制剂地昔帕明治疗的大鼠以及海马中去甲肾上腺素能神经元受DSP4损伤的大鼠均抑制了MDMA诱导的海马而不是纹状体中多巴胺细胞外浓度的增加-（2-氯乙基）-N-乙基-2-溴苄胺）。但是，在地昔帕明治疗的大鼠中，由MDMA产生的海马中5-HT的长期消耗没有改变。这些结果支持以下观点：MDMA诱导海马中多巴胺的细胞外浓度增加是由于去甲肾上腺素能神经元释放多巴胺增加的结果。此外，MDMA诱导的海马5-HT耗竭似乎不涉及多巴胺引发的过程，因为抑制MDMA诱导的多巴胺释放不会减弱海马5-HT的长期耗竭。

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