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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol exposure during either adolescence or adulthood alters the rewarding effects of cocaine in adult rats
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Ethanol exposure during either adolescence or adulthood alters the rewarding effects of cocaine in adult rats

机译：青春期或成年期的乙醇暴露会改变可卡因对成年大鼠的奖励作用

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Objectives: The present studies assessed the effects of adolescent and adult ethanol exposure on the rewarding effects of cocaine as measured with the conditioned place preference procedure. Methods: Male rats were exposed to intraperitoneal (IP) injections of ethanol or vehicle for 10 days [postnatal days (PNDs) 30-39 or PNDs 70-79; 2 mg/kg]. Place preference conditioning began on PND 65 or PND 105, respectively, and consisted of a baseline test followed by four conditioning cycles with either 0, 5, 10 or 20 mg/kg cocaine. Following the fourth conditioning cycle a final preference test was performed. Changes in time on the drug-paired side between the baseline and final test were analyzed. Results: Animals exposed to vehicle (during adolescence or adulthood) showed a significant place preference at 20 mg/kg cocaine. Animals exposed to ethanol (during adolescence or adulthood) showed a significant place preference at 10 mg/kg cocaine. Conclusions: Exposure to ethanol (adolescents or adults) sensitized the rewarding effects of cocaine. This may indicate an increase in the abuse liability of cocaine following a history of ethanol exposure.
机译：目的：本研究评估了青少年和成人乙醇暴露对可卡因的奖励作用的影响，该条件可通过条件性场所偏爱程序进行测量。方法：将雄性大鼠腹膜内（IP）乙醇或媒介物注射10天[产后天数（PNDs）30-39或PNDs 70-79; 2 mg / kg]。位置偏好调理分别在PND 65或PND 105上开始，包括基线测试，接着是四个以0、5、10或20 mg / kg可卡因进行的调理周期。在第四条件循环之后，进行最终的偏好测试。分析了基线和最终测试之间在药物配对方面的时间变化。结果：暴露于媒介物的动物（在青春期或成年期）以20 mg / kg可卡因表现出明显的位置偏爱。暴露于乙醇的动物（青春期或成年期）以10 mg / kg可卡因表现出明显的位置偏爱。结论：暴露于乙醇（青少年或成人）会增加可卡因的奖励作用。这可能表明在暴露于乙醇后，可卡因的滥用责任增加。

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