• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response.
【24h】

The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response.

机译：多巴胺能药物在尼古丁诱发的类似焦虑的反应中对小鼠海马的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

RATIONALE: Nicotine, an active alkaloid of tobacco has an acetylcholine property that alters anxiety-like behaviors in rodents. Moreover, several investigations suggest that the mesolimbic/cortical dopamine systems to be involved in the drugs affecting anxiety. The dopaminergic modulation of acetylcholine synaptic transmission has also been also suggested by different studies. Furthermore, modulation of such behaviors in rodents may be mediated through the dorsal hippocampus. OBJECTIVES: In the present study, a possible role of the dorsal hippocampal acetylcholine receptor mechanism in nicotine's influence on anxiogenic-like responses has been investigated. METHODS: During test sessions, the hole-board was used to investigate the effects of SCH23390, sulpiride, SKF38393 and quipirole on nicotine response in mice. RESULTS: Intraperitoneal (i.p.) administration of nicotine (0.5 mg/kg) decreased the number of head dips but had no effect on other behaviors. Intra-dorsal hippocampal injections of ineffective doses of SCH23390 (SCH; 0.125 and 0.25 mug/mouse) or sulpiride (SUL; 0.5 and 0.75 mug/mouse) reversed head dips induced by nicotine but did not impact other exploratory behaviors. Furthermore, co-administration of ineffective doses of SKF38393 (SKF; 4 mug/mouse, dorsal hippocampus) or quipirole (QUI; 0.5 mug/mouse) in conjunction with an ineffective dose of nicotine (0.25 mg/kg, i.p.) decreased head dips induced by nicotine, but were otherwise ineffective. CONCLUSION: These results may indicate a modulatory effect for the dorsal hippocampus dopamine receptors (D and D) on an anxiogenic-like response induced by nicotine.
机译：理由：尼古丁是烟草的活性生物碱，具有乙酰胆碱性质，可改变啮齿动物的焦虑样行为。此外，一些研究表明中边缘/皮质多巴胺系统参与影响焦虑症的药物。不同的研究也提示了乙酰胆碱突触传递的多巴胺能调节。此外，啮齿类动物中此类行为的调节可通过背侧海马介导。目的：在本研究中，已研究了海马背侧乙酰胆碱受体机制在尼古丁对血管生成样反应的影响中的可能作用。方法：在测试过程中，使用孔板来研究SCH23390，舒必利，SKF38393和quipirole对小鼠尼古丁反应的影响。结果：腹膜内（i.p.）给予烟碱（0.5 mg / kg）可以减少头倾倒次数，但对其他行为没有影响。无效剂量的SCH23390（SCH; 0.125和0.25杯/小鼠）或舒必利（SUL; 0.5和0.75杯/小鼠）的背侧海马腔内注射可逆转尼古丁引起的头倾，但不会影响其他探索行为。此外，与无效剂量的尼古丁（0.25 mg / kg，腹膜内）联合使用无效剂量的SKF38393（SKF; 4个杯子/小鼠，背侧海马）或喹吡罗（QUI; 0.5个杯子/小鼠）与无效剂量由尼古丁诱导，但无效。结论：这些结果可能表明对海马背侧多巴胺受体（D和D）的调节作用是由烟碱引起的类似焦虑的反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号