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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Post-injury repeated administrations of minocycline improve the antinociceptive effect of morphine in chronic constriction injury model of neuropathic pain in rat
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Post-injury repeated administrations of minocycline improve the antinociceptive effect of morphine in chronic constriction injury model of neuropathic pain in rat

机译：损伤后反复给予美满霉素可改善吗啡在大鼠神经性疼痛慢性收缩性损伤模型中的镇痛作用

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It is confirmed that pharmacological attenuation of glial cells can alleviate neuropathic pain by lowering proinflammatory cytokine expression. The present study tries to confirm that post-injury administration of glia inhibitor, minocycline, can attenuate the neuropathic pain symptoms and improves the efficacy of morphine anti-nociception in chronic constriction injury (CCI). Male Wistar rats (230-270 g) underwent surgery for induction CCI model of neuropathy. For assessment of the thermal hyperalgesia and mechanical allodynia after CCI induction, morphine (2.5, 5, 7.5, 10 and 15 mg/kg; s.c.) and saline were administered on post-operative days (PODs) 0, 6 and 14. Hargreaves and Von-Frey tests were performed before and 30 min after morphine administration, respectively. The results showed significant decrease in antinociceptive effect of morphine on POD 6 compared to POD 0 only at the dose of 5 mg/kg. On the other hand, on POD 14 the antinociceptive effect of morphine (5, 7.5, 10 and 15 mg/kg) significantly decreased in comparison with POD 0. In another set of experiments, animals received minocycline (10, 20 and 40 mg/kg; i.p.) for eight days from POD 6 to 13 and then the antinociceptive effect of single dose of morphine 5 mg/kg was tested on POD 14. Behavioral tests showed that minocycline (40 mg/kg) could effectively attenuate the thermal hyperalgesia and mechanical allodynia on POD 13. Moreover, minocycline (40, 20 mg/kg) improved the anti-hyperalgesic, and minocycline (40 mg/kg) improved the anti-allodynic effects of morphine 5 mg/kg on POD 14. It seems that the reduction of antinociceptive effect of morphine after CCI may be mediated through glia activation. Modulation of glial activity by minocycline can attenuate CCI-induced neuropathic pain. It is also shown that repeated post-injury administration of minocycline improves the antinociceptive effect of morphine in neuropathic pain.
机译：证实胶质细胞的药理学减毒可通过降低促炎细胞因子的表达来减轻神经性疼痛。本研究试图证实，神经胶质抑制剂米诺环素的损伤后给药可以减轻神经性疼痛症状，并提高吗啡抗伤害感受在慢性收缩性损伤（CCI）中的疗效。对雄性Wistar大鼠（230-270 g）进行手术，以诱导其CCI神经病模型。为了评估CCI诱导后的热痛觉过敏和机械性异常性疼痛，在术后第0、6和14天（POD）施用吗啡（2.5、5、7.5、10和15 mg / kg; sc）和生理盐水。分别在吗啡给药前和给药后30分钟进行Von-Frey试验。结果表明，与仅在5 mg / kg的剂量下的POD 0相比，吗啡对POD 6的抗伤害感受作用显着降低。另一方面，与POD 0相比，在POD 14上，吗啡的镇痛作用（5、7.5、10和15 mg / kg）显着降低。在另一组实验中，动物接受了米诺环素（10、20和40 mg / kg从POD 6到13连续八天，然后在POD 14上测试5 mg / kg单剂量吗啡的镇痛作用。行为测试表明，米诺环素（40 mg / kg）可以有效减轻热痛觉过敏。机械性异常性疼痛对POD 13的影响。此外，米诺环素（40，20 mg / kg）改善了抗痛觉过敏，米诺环素（40 mg / kg）改善了5 mg / kg吗啡对POD 14的抗痛觉过敏作用。 CCI后吗啡的抗伤害感受作用的降低可能是通过胶质细胞激活介导的。米诺环素对神经胶质活动的调节可以减轻CCI诱导的神经性疼痛。还显示了米诺环素的损伤后重复给药改善了吗啡在神经性疼痛中的抗伤害感受作用。

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