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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differential effect of low doses of intracerebroventricular corticotropin-releasing factor in forced swimming test.
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Differential effect of low doses of intracerebroventricular corticotropin-releasing factor in forced swimming test.

机译：低剂量脑室皮质激素释放因子在强迫游泳试验中的差异作用。

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In this work, we studied the effect of low doses of intracerebroventricular corticotropin-releasing factor (CRF) in six sessions of forced swimming test (FST). When CRF (0.01 and 0.1 microg) was administered pre-test, results showed that the 0.1-microg dose significantly increased swimming in SESSION2, SESSION3 and SESSION4, while the 0.01-microg dose proved ineffective. When CRF (0.1 and 0.03 microg) was administered post-test to evaluate retention of swimming response, the dose of 0.1 microg impaired retention, while the dose of 0.03 microg improved it, although these effects only reached significance in SESSION2. In an additional session (SESSION6), testing long-term retention of this swimming response, the 0.1-microg dose significantly impaired retention, whereas the 0.03-microg dose proved ineffective. A high dose of CRF (1 microg) was also included as a control of previous results [Garcia-Lecumberri C, Ambrosio E. Role of corticotropin-releasing factor in forced swimming test. Eur J Pharmacol 1998;343:17-26]. In all the FST sessions, this high dose increased swimming when administered pre-test, while impairing retention when administered post-test. Preliminary data obtained with low doses of CRF suggest that a differential effect on retention of swimming response seems to exist depending on the dose, whereas a high dose of CRF clearly impairs retention. The role of CRF in learning and memory processes in FST is discussed.
机译：在这项工作中，我们研究了六次强迫游泳试验（FST）中低剂量脑室皮质激素释放因子（CRF）的作用。当进行CRF（0.01和0.1微克）的预测试时，结果显示0.1微克剂量显着增加了SESSION2，SESSION3和SESSION4中的游泳，而0.01微克剂量被证明无效。测试后给予CRF（0.1和0.03微克）以评估游泳反应的保持力时，0.1微克的剂量会损害保持力，而0.03微克的剂量会改善其保持力，尽管这些效果仅在SESSION2中才有意义。在另外的会议（SESSION6）中，测试这种游泳反应的长期保留，0.1微克剂量显着损害了保留，而0.03微克剂量被证明无效。还包括高剂量的CRF（1微克）作为以前结果的对照[Garcia-Lecumberri C，Ambrosio E.促肾上腺皮质激素释放因子在强迫游泳试验中的作用。 Eur J Pharmacol 1998; 343：17-26]。在所有FST疗程中，这种高剂量在测试前给药时会增加游泳，而在测试后给药时会损害游泳能力。用低剂量的CRF获得的初步数据表明，似乎对游泳反应的保留存在不同的影响，具体取决于剂量，而高剂量的CRF明显损害了保留。讨论了CRF在FST中学习和记忆过程中的作用。

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