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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Non reciprocal cross-sensitization between cocaine and BTCP on locomotor activity in the rat.
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Non reciprocal cross-sensitization between cocaine and BTCP on locomotor activity in the rat.

机译：可卡因和BTCP之间对大鼠运动活动的非对等交叉致敏作用。

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Measurement of locomotor sensitization was employed to characterize the effect of intermittent treatment with N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine in the rat. Like cocaine, BTCP possesses high affinity for the dopamine transporter and inhibits dopamine reuptake. Although both drugs exhibit similar behavioral and neurochemical profiles with acute administration, there is tentative evidence to suggest that following chronic treatment BTCP does not induce neurochemical sensitization, and can attenuate cocaine-induced neurochemical sensitization in the striatum. Male Wistar rats were randomly divided into five groups after determining baseline locomotor activity. Three groups were treated with either saline (saline/saline), cocaine (20 mg/kg; cocaine/cocaine), or BTCP (10 mg/kg; BTCP/BTCP) for 10 days. The remaining two groups were treated with cocaine (20 mg/kg) or BTCP (10 mg/kg) for 3 days, followed by administration of BTCP (10 mg/kg; cocaine/BTCP) or cocaine (20 mg/kg; BTCP/cocaine) for 7 days. Locomotor sensitization was observed in all groups. However, although cross-sensitization on the day of substitution (day 4) was found in the BTCP/cocaine group, cross-sensitization was not observed in the cocaine/BTCP group. These results suggest that although the locomotor-activating effects of BTCP and cocaine are similar, the two drugs do not act identically, and different neural mechanisms may underlie BTCP and cocaineinduced sensitization.
机译：运动敏化的测量用于表征用N- [1-（2-（2-苯并[b]硫苯基）环己基]哌啶（BTCP）和可卡因在大鼠中间歇治疗的效果。像可卡因一样，BTCP对多巴胺转运蛋白具有高亲和力，并抑制多巴胺的再摄取。尽管两种药物在急性给药后均表现出相似的行为和神经化学特征，但有初步证据表明，长期治疗后BTCP不会诱导神经化学致敏，并能减弱​​可卡因引起的纹状体神经化学致敏。确定基线运动能力后，将雄性Wistar大鼠随机分为五组。三组分别用盐水（盐水/盐水），可卡因（20 mg / kg;可卡因/可卡因）或BTCP（10 mg / kg; BTCP / BTCP）治疗10天。其余两组分别用可卡因（20 mg / kg）或BTCP（10 mg / kg）治疗3天，然后施用BTCP（10 mg / kg;可卡因/ BTCP）或可卡因（20 mg / kg; BTCP） /可卡因）7天。在所有组中均观察到运动敏化。然而，尽管在BTCP /可卡因组中发现了替代日（第4天）的交叉致敏作用，但在可卡因/ BTCP组中未观察到交叉致敏作用。这些结果表明，尽管BTCP和可卡因的运动激活作用相似，但这两种药物的作用并不相同，并且不同的神经机制可能是BTCP和可卡因引起的敏化作用的基础。

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