Modeling the Kinetics of Protein Conjugation Reactions

Pfister David; Ulmer Nicole; Klaue Antoine; Ingold Oliver; Morbidelli Massimo

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Modeling the Kinetics of Protein Conjugation Reactions

机译：蛋白质偶联反应动力学模型

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Over the past decades, the pharmaceutical industry has shown a continuous infatuation for therapeutic proteins. In order to constantly improve their efficacy, chemical reactions involving the conjugation of the therapeutic protein with various chemical reagents have been developed. Little efforts have been put forth to simulate the kinetics of protein conjugation and the literature dealing with kinetic models is rather scarce as compared to the abundant references about conjugation reactions in general. In this work, techniques to measure the kinetics of reaction, model the conjugation between add-on molecules and proteins, and evaluate the model parameters are discussed.

机译：在过去的几十年中，制药行业对治疗性蛋白质表现出了持续的痴迷。为了不断提高其功效，已经开发出涉及治疗性蛋白质与各种化学试剂结合的化学反应。很少有人努力模拟蛋白质结合的动力学，并且与一般有关结合反应的大量参考文献相比，涉及动力学模型的文献很少。在这项工作中，讨论了测量反应动力学，对附加分子与蛋白质之间的结合进行建模以及评估模型参数的技术。

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《Chemie-Ingenieur-Technik: Verfahrenstechnik Technische Chemie Apparatewesen Biotechnologie》 |2016年第11期|共11页
作者
Pfister David; Ulmer Nicole; Klaue Antoine; Ingold Oliver; Morbidelli Massimo;
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正文语种 eng
中图分类化学工业;
关键词
Kinetic modeling; Parameters estimation; Protein conjugation; Therapeutic proteins;

机译：动力学建模;参数估计;蛋白质结合;治疗性蛋白质;

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1. Modeling the Kinetics of Protein Conjugation Reactions [J] . Pfister David, Ulmer Nicole, Klaue Antoine, Chemie-Ingenieur-Technik: Verfahrenstechnik Technische Chemie Apparatewesen Biotechnologie . 2016,第11期

机译：蛋白质偶联反应动力学模型
2. Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein [J] . Xu Shengsheng, Kaltashov Igor A. Molecular pharmaceutics . 2017,第8期

机译：克服反应中间体在生产蛋白质/药物缀合物中的水解型易损伤：将无核苷核酸膦酸酯缀合到模型载体蛋白
3. Improved adsorption reactions, kinetics and stability for model and therapeutic proteins immobilised on affinity resins [J] . Hedberg S. H. M., Brown L. G., Meghdadi A., Adsorption . 2019,第6期

机译：改善了对亲和树脂固定化的模型和治疗蛋白质的吸附反应，动力学和稳定性
4. Optimization of Protein PEGylation Reaction using Design of Experiments (DOE) and Kinetic Modeling [C] . Amol Ketkar, Donna Lee, Ping Yeh, Controlled Release Society annual meeting . 2004

机译：使用实验设计（DOE）和动力学模型优化蛋白质PEG化反应
5. Kinetics of oxidation-reduction reactions on the surface of birnessite: X-ray photoelectron study of iron(II) oxidation and Monte Carlo modelling of iron(II) and chromium(III) oxidation kinetics. [D] . Vanderspiegel, Rebecca. 2009

机译：水钠锰矿表面氧化还原反应的动力学：铁（II）氧化的X射线光电子研究和铁（II）和铬（III）氧化动力学的蒙特卡罗模拟。
6. Improved adsorption reactions kinetics and stability for model and therapeutic proteins immobilised on affinity resins [O] . S. H. M. Hedberg, L. G. Brown, A. Meghdadi, -1

机译：固定在亲和树脂上的模型和治疗蛋白的吸附反应动力学和稳定性得到改善
7. Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of 177LuLu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model [O] . Judith Anna Delage, Alain Faivre-Chauvet, Jacques Barbet, 2021

机译：DOTA缀合对177LU Lu-1C1M-FC的药代动力学和免疫反应性的影响，TEM-1阳性肿瘤小鼠模型中的抗TEM-1融合蛋白抗体。

Modeling the Kinetics of Protein Conjugation Reactions

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