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首页> 美国政府科技报告 >Effect of Adrenalectomy and Dexamethasone on the Antinociceptive Effects of Physostigimine
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Effect of Adrenalectomy and Dexamethasone on the Antinociceptive Effects of Physostigimine

机译：肾上腺切除术和地塞米松对physostigimine镇痛作用的影响

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The tail-flick procedure was used to study the antinociceptive effects of physostigmine in adrenalectomized and sham-operated rats. At 5 days after surgery, they were tested 30 minutes after either 0.32 or 0.45 mg/kg IP physostigmine. Adrenalectomized animals showed significantly greater elevation of TF scores from predrug latencies than the sham controls at both doses of physostigmine. Following 3 days of dexamethasone replacement therapy on days 18, 19, and 20 postsurgery the antinociceptive effects of physostigmine were uniformly attenuated across dose or surgical groups. On the other hand, animals receiving saline rejection instead of dexamethasone did not manifest any reduction of the physostigmine antinociceptive effect. The potentiation by adrenalectomy and the reduction following dexamethasone of the antinociceptive effects of physostigmine suggest that these effects may be mediated through hypothalamic-pituitary-adrenal mechanisms and are consistent with B-endorphin-induced sensitization of opiate or cholinergic receptors.

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