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PHAGE-SENSITIVE STREPTOCOCCUS THERMOPHILUS

机译：噬菌体嗜热链球菌

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摘要

Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.

机译：产生了三种嗜热链球菌亲本菌株的噬菌体不敏感突变体（BIM），并对其噬菌体敏感性，沉降速率，细胞链长度，噬菌体吸附和CRISPR基因座改变进行了表征。几个BIM在三个CRISPR基因座中显示出改变的沉降表型以及增加的细胞链长度，降低的噬菌体敏感性，降低的噬菌体吸附和100％的同一性。结果表明，衍生的BIM通过除CRISPR之外的其他机制已变得抗噬菌体。

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公开/公告号DK3116994T3

专利类型
公开/公告日2019-10-21

原文格式PDF
申请/专利权人 DSM IP ASSETS B.V.;
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申请/专利号DK20150706002T
发明设计人 KOUWEN ROELOF HENDRIK MATTHIJS;HEE VAN PIM;VAN SINDEREN DOUWE;MCDONNELL BRIAN;MAHONY JENNIFER;
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申请日2015-02-20
分类号C12N15/10;A23C9/123;A23C19/032;C12N1/04;C12N1/20;C12Q1/689;C12R1/46;
国家 DK
入库时间 2022-08-21 12:02:39

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