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PRODUCING WHEY PROTEIN CONCENTRATE RICH IN IMMUNOGLOBULINS USING MEMBRANE ULTRAFILTRATION OR ANION EXCHANGE RESIN
PRODUCING WHEY PROTEIN CONCENTRATE RICH IN IMMUNOGLOBULINS USING MEMBRANE ULTRAFILTRATION OR ANION EXCHANGE RESIN
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机译：使用膜超滤或阴离子交换树脂生产富含免疫球蛋白的乳清蛋白浓缩物
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摘要
The present invention provides a method of producing a whey protein concentrate rich in immunoglobulins which comprises fractionating whey proteins into an immunoglobulins rich fraction and an immunoglobulins depleted fraction and concentrating at least the immunoglobulins rich fraction, characterised by either (i) subjecting a whey, a liquid whey protein concentrate or a reconstituted whey protein concentrate powder to ultrafiltration through a membrane having a molecular weight cut-off of substantially 500,000 whereby to directly produce an immunoglobulins enriched concentrate together with fat, the permeate containing at least a major proportion of the remaining whey proteins, or (ii) subjecting whey or a liquid whey protein concentrate to the action of an anion-exchange resin to produce an effluent, the whey proteins in which contain a higher proportion of immunoglobulins than those in the original whey or whey protein concentrate and an eluate the whey protein content of which contains a depleted proportion of immunoglobulins and subjecting at least the effluent to concentration by ultrafiltration. h
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机译：本发明提供了一种生产富含免疫球蛋白的乳清蛋白浓缩物的方法，该方法包括将乳清蛋白分离成富含免疫球蛋白的级分和缺乏免疫球蛋白的级分，并至少浓缩富含免疫球蛋白的级分，其特征在于（i）使乳清，蛋白质或蛋白乳化。液体乳清蛋白浓缩物或重组乳清蛋白浓缩物粉末通过截留分子量约为500,000的膜进行超滤，从而直接生产富含免疫球蛋白的浓缩物和脂肪，渗透液至少包含大部分剩余的乳清（ii）使乳清或液态乳清蛋白浓缩物经受阴离子交换树脂的作用以产生流出物，其中乳清蛋白中的免疫球蛋白比例要高于原始乳清或乳清蛋白浓缩物中的免疫球蛋白比例，并且洗脱液中的乳清蛋白含量免疫球蛋白的消耗比例降低，并且至少要通过超滤对流出液进行浓缩。 H
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