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Fabrication of microstructures using the DMD-based modulating projection printing method

机译：使用基于DMD的调制投影印刷方法制造微结构

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Patterned microstructures of hydrogels have attracted significant attention due to an increasing need for developing scaffolds for tissue engineering, as carriers for drug delivery, and as extracellular matrices for biological studies. However, current tissue engineering approaches lack the flexibility required for developing complex two or three-dimensional (2D/3D) microstructures, which are used to impart suitable cell mechanical microenvironments. In this paper, we present an ultraviolet (UV) light curing method based on a digital mirror device-based modulating projection printing (DMPP) system for fabricating patterned poly(ethylene glycol) diacrylate (PEGDA) hydrogel microstructures. With programmable UV exposure, polymerisation of the PEGDA solution can be induced to create 2D/3D microstructures with high biocompatibility. The main advantage of DMPP is that it is a mask-free method. In addition, the efficiency of the DMPP method is much higher than other methods for patterning PEGDA microstructures. The duration of UV exposure was less than 10 s. In the experiments described below, several types of microstructure arrays have been fabricated. These initial results show that the DMPP method can be used for fabricating highly complex microstructures with controlled accuracy.
机译：由于对开发用于组织工程的支架，作为药物递送的载体以及作为生物学研究的细胞外基质的需求不断增加，水凝胶的图案化微结构引起了广泛的关注。但是，当前的组织工程学方法缺乏开发复杂的二维或三维（2D / 3D）微观结构所需的灵活性，该结构用于赋予合适的细胞机械微环境。在本文中，我们提出了一种基于数字镜面设备的基于调制投影印刷（DMPP）系统的紫外（UV）光固化方法，用于制造图案化的聚（乙二醇）二丙烯酸酯（PEGDA）水凝胶微结构。通过可编程的紫外线曝光，可以诱导PEGDA溶液的聚合，以产生具有高生物相容性的2D / 3D微结构。 DMPP的主要优点是它是一种无掩模的方法。此外，DMPP方法的效率比其他用于图案化PEGDA微结构的方法要高得多。紫外线照射的持续时间少于10 s。在下面描述的实验中，已经制造了几种类型的微结构阵列。这些初步结果表明，DMPP方法可用于制造具有可控精度的高度复杂的微结构。

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