Preventing Hypoxia-induced Beta Cell Death and Dysfunction via Oxygen-generating Microbeads

机译：通过产生氧气的微珠预防缺氧诱导的β细胞死亡和功能障碍

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The OxySite biomaterial can be reproducibly fabricated into a microbead form within the desired size range. These microbeads can generate oxygen for more than 30 days, with minimal cytotoxic byproducts or environmental changes. Compared to control PDMS-only microbeads, the co-culture of beta cells with OxySite microbeads within immunoisolatory agarose macrogels resulted in sustained and significant elevations in viability and functionality under hypoxic condition in vitro. With these promising results, and the flexibility of the OxySite microbead platform, this approach could be easily translated to numerous tissue engineered platforms. Future work will explore the potential of this platform to improve efficacy of transplants in diabetic mice.

机译：OxySite生物材料可以可复制地制成所需大小范围内的微珠形式。这些微珠可产生氧气超过30天，而细胞毒性副产物或环境变化最小。与仅使用PDMS的对照微珠相比，β细胞与OxySite微珠在免疫隔离琼脂糖大凝胶中的共培养导致体外低氧条件下活力和功能的持续显着提高。有了这些令人鼓舞的结果，以及OxySite微珠平台的灵活性，这种方法可以轻松地转化为众多组织工程平台。未来的工作将探索该平台改善糖尿病小鼠移植功效的潜力。

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《Society for Biomaterials annual meeting and exposition》|2018年|582-582|共1页
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Jia-Pu Liang; Maria Coronel; Minh Dang; Cherie Stabler;
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1. Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated,oxygen-generating biomaterials [J] . Eileen Pedraza, Maria M. Coronel, Christopher A. Fraker, Proceedings of the National Academy of Sciences of the United States of America . 2012,第11期

机译：通过水解激活的产氧生物材料防止低氧诱导的β细胞和胰岛细胞死亡
2. OVEREXPRESSION OF CELLULAR PRION PROTEIN (PRPC) PREVENTS COGNITIVE DYSFUNCTION AND APOPTOTIC NEURONAL CELL DEATH INDUCED BY AMYLOID-beta (AB_(1-40)) ADMINISTRATION IN MICE [J] . D. RIAL, T. C. PIERMARTIRI, F. S. DUARTE, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2012,第Null期

机译：过度表达细胞PR蛋白（PRPC）预防淀粉样β（AB_（1-40））诱导的小鼠认知功能障碍和凋亡性神经细胞死亡
3. Protective effects of (Gly14)-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction. [J] . Jin H, Liu T, Wang WX, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2010,第3期

机译：（Gly14）-Humanin通过预防线粒体功能障碍对β-淀粉样蛋白诱导的PC12细胞死亡的保护作用。
4. Preventing Hypoxia-induced Beta Cell Death and Dysfunction via Oxygen-generating Microbeads [C] . Jia-Pu Liang, Maria Coronel, Minh Dang, Society for Biomaterials annual meeting and exposition . 2018

机译：通过氧气产生微珠预防缺氧诱导的β细胞死亡和功能障碍
5. Protective role of protein kinase B/Akt against mitochondrial dysfunction and cell death in nephrotoxicant injured renal cells . [D] . Shaik, Zabeena Parveen. 2007

机译：蛋白激酶B / Akt对肾毒性肾细胞线粒体功能障碍和细胞死亡的保护作用。
6. Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated oxygen-generating biomaterials [O] . Eileen Pedraza, Maria M. Coronel, Christopher A. Fraker, 2012

机译：通过水解激活的可产生氧气的生物材料防止低氧诱导的β细胞和胰岛细胞死亡
7. Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials [O] . E. Pedraza, M. M. Coronel, C. A. Fraker, 2012

机译：通过水解活化的氧气产生生物材料预防β细胞和胰岛中缺氧诱导的细胞死亡

Preventing Hypoxia-induced Beta Cell Death and Dysfunction via Oxygen-generating Microbeads

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