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BioMEMS for high-throughput handling and microinjection of embryos

机译：用于高通量处理和胚胎微调的生物邮件

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Technologies for handling, sorting, and positioning of embryos are increasingly important in biomedicine. In this paper the status for ongoing projects aimed at developing instrumentation for high-throughput treatment of embryos is reviewed. Techniques for positioning of Drosophila (fruit-fly) embryos in 2-D arrays for use in microinjection experiments are especially focused. A method based on fluidic micro assembly is discussed, and important parameters such as immobilization yield, the number of misplaced embryos, and adhesion force of the embryos are reported. A model for the assembly process is described, and simulation results are in good agreement with adhesion force measurements. A fully automated MEMS based system for fruit-fly embryo injection has recently been demonstrated at Stanford University. The first experiments with double-stranded RNA injection proved successful, and the expected genetic modification of the embryos was observed.
机译：用于处理，分类和定位胚胎的技术在生物医学中越来越重要。在本文中，综述了旨在开发胚胎的高通量治疗仪器仪表的持续项目的地位。特别聚焦在2-D阵列中使用的果蝇（果蝇）胚胎中的果蝇（果蝇）胚胎的技术尤其集中。讨论了一种基于流体微组件的方法，报道了重要的参数，例如固定产率，错位胚胎的数量和胚胎的粘附力。描述了组装过程的模型，仿真结果与粘附力测量很好。最近在斯坦福大学证明了基于果蝇胚胎注射的全自动MEMS系统。具有双链RNA注射的第一个实验证明是成功的，并且观察到胚胎的预期遗传修饰。

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