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首页> 外文会议>Proceedings of international symposium on crystal engineering and drug delivery system 2009 >Study on the Oral Self-Microemulsifying Drug Delivery System of GBE50
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Study on the Oral Self-Microemulsifying Drug Delivery System of GBE50

机译：GBE50口服自微乳化给药系统的研究

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@@Self-Microemulsifying Drug Delivery System (SMEDDS) is composed of drug, oil phase, emulsifier and assistant emulsifier. It is homogeneous, transparent solution. The drug which is insoluble in water could be spontaneously emulsified to form microemulsion with particle size 10 ~ 100nm when mixing with water phase under the ambient temperature and moderate mixing conditions. SMEDDS system could enhance drug solubility and absorbability in human body and increase bioavailability in the clinic practice. It also reduces stimulation by drugs in the gastrointestinal wall when directly contacting it and avoids hydrolysis of the unstable drugs in water and the adverse stimulus of drugs on the gastrointestinal tract. GBE50 extracts from the Ginkgo biloba leaf. It is product of second-class medicine approved by the State Food and Drug Administration, having a special aroma, bitter taste. It contains flavonoid glycosides, terpene lactones, and so on. The main chemical composition include the total flavonoids of Ginkgo(≥ 44%), flavone glycosides(≥ 24%), free flavonoids(≥ 20%); terpene lactones (≥ 6%); ginkgolic acid (≤ 5ppm).
机译：自我微乳化药物输送系统（SMEDDS）由药物，油相，乳化剂和辅助乳化剂组成。它是均匀，透明的解决方案。在环境温度和适度混合条件下与水相混合时，不溶于水的药物可自发乳化形成粒径为10〜100nm的微乳状液。 SMEDDS系统可以提高药物在人体中的溶解度和吸收性，并在临床实践中提高生物利用度。当直接接触胃肠道壁时，它还减少了药物对胃肠道壁的刺激，并避免了水中不稳定药物的水解和药物对胃肠道的不利刺激。 GBE50从银杏叶中提取。它是国家食品药品监督管理局批准的二级药品，具有特殊的香气，苦味。它包含类黄酮糖苷，萜内酯等。主要化学成分包括银杏总黄酮（≥44％），黄酮苷（≥24％），游离黄酮（≥20％）；萜内酯（≥6％）;银杏酸（≤5ppm）。

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