Objective To investigate the relationship among ambulatory pulse pressure index ( PPI ) , carotid intima-media thickness ( IMT ) and high-sensitivity C—reactive protein ( hs—CRP ) . Methods The patients ( n=116 ) with essential hypertension ( EH ) were selected as EH group from May, 2011 to July, 2012, and then, according to their PPI, divided into three subgroups ( group A: PPI≤0.40 and n=39, group B: 0.41 ^ PPI<0.50 and n=A, group C: PPI&0.50 and n=36). At the same time 89 healthy controls were selected as control group. The level of serum hs-CRP was detected by using automatic immune nephelometry, IMT was detected by using color ultrasonograph, and levels of IMT and hs-CRP were compared between two groups. Results ①The levels of PPI, IMT and hs—CRP were all higher in EH group than those in control group. ②CA—IMT increased along with the increase of PPI, and they were correlated to each other ( r=0.797 ) . ③Hs—CRP increased along with the increase of PPI, and they were correlated to each other ( r=0.734 ) . Conclusion PPI is higher in EH patients than that in healthy people, and it is a risk factor of IMT and hs—CRP.%目的 探讨脉压指数(PPI)与颈动脉内膜-中膜厚度(IMT)及超敏C反应蛋白(hs-CRP)的关系.方法 纳入2011年5月～2012年7月原发性高血压(EH)患者116例作为高血压组,并按照PPI分为3个亚组(A组:PPI≤0.40,n=39;B组:0.41≤PPI＜0.50,n=41;C组:PPI≥0.50,n=36);同期纳入健康体检者89例作为对照组.应用全自动免疫散射比浊法检测血清hs-CRP,超声检测IMT,比较不同组颈动脉IMT及hs-CRP 水平.结果 ①高血压组PPI、颈动脉IMT和hs-CRP均高于对照组;②随着PPI的增加,颈动脉IMT随之增加,二者呈正相关(r=0.797,P＜0.001);③随着PPI的增加,hs-CRP也随之增加,二者呈正相关性(r=0.734,P＜0.001).结论 原发性高血压患者PPI较健康人群高,且PPI与颈动脉IMT和hs-CRP具有相关性.
展开▼
