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Identification Modeling and Ligand Affinity of Early Deuterostome CYP51s and Functional Characterization of Recombinant Zebrafish Sterol 14α-Demethylase

机译：早期氘核CYP51s的鉴定建模和配体亲和力以及重组斑马鱼固醇14α-脱甲基酶的功能表征

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BackgroundSterol 14α-demethylase (cytochrome P450 51, CYP51, P45014DM) is a microsomal enzyme that in eukaryotes catalyzes formation of sterols essential for cell membrane function and as precursors in biosynthesis of steroid hormones. Functional properties of CYP51s are unknown in non-mammalian deuterostomes.

机译：背景固醇14α-脱甲基酶（细胞色素P450 51，CYP51，P45014DM）是一种微粒体酶，在真核生物中催化形成对于细胞膜功能必不可少的甾醇并作为甾体激素生物合成的前体。 CYP51s的功能特性在非哺乳动物的氘化吻合器中是未知的。

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期刊名称 other
作者
Ann Michelle Stanley Morrison; Jared V. Goldstone; David C. Lamb; Akira Kubota; Benjamin Lemaire; John. J. Stegeman;
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年(卷),期 -1(1840),6
年度 -1
页码 1825–1836
总页数 31
原文格式 PDF
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关键词
Sterol 14α-demethylase CYP51 zebrafish deuterostomes sterol biosynthesis azole inhibition;

机译：甾醇14α-脱甲基酶;CYP51;斑马鱼;氘化子宫;固醇生物合成;唑类抑制;

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1. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase [J] . MorrisonA.M.S., GoldstoneJ.V., LambD.C., Biochimica et Biophysica Acta. General Subjects . 2014,第6期

机译：早期氘核CYP51s的鉴定，建模和配体亲和力以及重组斑马鱼固醇14α-脱甲基酶的功能表征
2. Azole Affinity of Sterol 14-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens [J] . WarrilowA.G., ParkerJ.E., KellyD.E., Antimicrobial agents and chemotherapy. . 2013,第3期

机译：白色念珠菌和智人的甾醇14-脱甲基酶（CYP51）酶的偶氮亲和力
3. Validation of Human Sterol 14 alpha-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors [J] . Friggeri Laura, Hargrove Tatiana Y., Wawrzak Zdzislaw, Journal of Medicinal Chemistry . 2019,第22期

机译：人甾醇14α-脱甲基酶（CYP51）可耐药性：结构引导的设计，合成和化学计量，功能性不可逆抑制剂的评价
4. The Construction and Characterization of Self-sufficient Sterol 14-Demethylase Fusion Proteins consisting of Yeast CYP51 and NADPH-450 reductase [C] . Kitahama Y., Nakamura M., Yoshida Y. Aoyama Y International Conference on Cytochrome P450 . 2009

机译：由酵母CYP51和NADPH-450还原酶组成的自给式甾醇14-脱甲基酶融合蛋白的构建与表征
5. Host-Induced Gene Silencing (HIGS) of the Fungal Cytochrome P450 Lanosterol C-14A-Demethylase (CYP51) Could Confer Resistance to Fusarium verticillioides in Maize [D] . Crenshaw, Nicole Jozwiak. 2020

机译：真菌细胞色素P450 Lanterol醇C-14A-脱甲基酶（CYP51）的宿主诱导的基因沉默（HIGS）可以赋予玉米中镰刀菌的镰刀菌
6. Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens [O] . Andrew G. Warrilow, Josie E. Parker, Diane E. Kelly, 2013

机译：白色念珠菌和智人的甾醇14CY-脱甲基酶（CYP51）酶的偶氮亲和力
7. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase [O] . Lamb, David 2014

机译：早期deuterostome CYp51s的鉴定，建模和配体亲和力，以及重组斑马鱼甾醇14α-去甲基化酶的功能表征

Identification Modeling and Ligand Affinity of Early Deuterostome CYP51s and Functional Characterization of Recombinant Zebrafish Sterol 14α-Demethylase

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