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Vitamin D and Gestational Diabetes Mellitus: Is There a Link?

机译：维生素D和妊娠糖尿病：有联系吗？

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摘要

Gestational diabetes mellitus (GDM) is a very common condition among pregnant women worldwide with important metabolic implications on the mother and the offspring. Vitamin D status has been suggested to potentially play a role in GDM risk with no documented consequences for the offspring. The purpose of this article was to review currently available evidence on the relationship between vitamin D and GDM. Current evidence shows an association between vitamin D blood levels and risk of GDM, despite heterogeneity of results across studies limit the conclusions. Moreover, data from randomized controlled trials is scarce and resulting in null findings. Among the limitations to be noted, improving the standardization of dosages, the characteristics of individuals in the sample, and the appropriate outcome measurement could provide a more effective approach in understanding the relationship between vitamin D and GDM. In conclusions, despite observational studies may suggest that adequate vitamin D levels may decrease the risk of GDM compared to deficiency status, evidence from clinical trials is inadequate to draft any definitive conclusion regarding its supplementation. Future better designed randomized clinical trials taking into account a more integrated approach could provide clearer and definitive data on the outcomes of such a multifactorial condition.
机译：妊娠期糖尿病（GDM）是全世界孕妇中非常普遍的疾病，对母亲和后代都有重要的代谢影响。维生素D的状态已被暗示可能在GDM风险中起作用，而对后代没有任何记录的后果。本文的目的是回顾有关维生素D和GDM之间关系的现有证据。尽管各研究结果的异质性限制了结论，但目前的证据表明维生素D血液水平与GDM风险之间存在关联。此外，来自随机对照试验的数据稀少，导致无效发现。在需要注意的局限性中，改善剂量的标准化，样品中个体的特征以及适当的结果测量可提供一种更有效的方法，以了解维生素D和GDM之间的关系。结论是，尽管观察性研究可能表明，与缺乏状态相比，适当的维生素D水平可以降低GDM的风险，但临床试验的证据不足以起草关于其补充的任何明确结论。考虑到更综合的方法，未来设计更好的随机临床试验可能会提供有关这种多因素疾病结局的更清晰和确定的数据。

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